Cell and Tissue Research

, Volume 341, Issue 1, pp 23–32

LPA receptor expression in the central nervous system in health and following injury

Regular Article

DOI: 10.1007/s00441-010-0977-5

Cite this article as:
Goldshmit, Y., Munro, K., Leong, S.Y. et al. Cell Tissue Res (2010) 341: 23. doi:10.1007/s00441-010-0977-5

Abstract

Lysophosphatidic acid (LPA) is released from platelets following injury and also plays a role in neural development but little is known about its effects in the adult central nervous system (CNS). We have examined the expression of LPA receptors 1-3 (LPA1–3) in intact mouse spinal cord and cortical tissues and following injury. In intact and injured tissues, LPA1 was expressed by ependymal cells in the central canal of the spinal cord and was upregulated in reactive astrocytes following spinal cord injury. LPA2 showed low expression in intact CNS tissue, on grey matter astrocytes in spinal cord and in ependymal cells lining the lateral ventricle. Following injury, its expression was upregulated on astrocytes in both cortex and spinal cord. LPA3 showed low expression in intact CNS tissue, viz. on cortical neurons and motor neurons in the spinal cord, and was upregulated on neurons in both regions after injury. Therefore, LPA1–3 are differentially expressed in the CNS and their expression is upregulated in response to injury. LPA release following CNS injury may have different consequences for each cell type because of this differential expression in the adult nervous system.

Keywords

Lysophosphatidic acid LPA receptor Spinal cord injury Cortical injury neurotrauma Mouse (C57BL/6) 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Centre for NeuroscienceThe University of MelbourneVictoriaAustralia
  2. 2.Department of PharmacologyThe University of MelbourneVictoriaAustralia
  3. 3.Australian Regenerative Medicine InstituteMonash UniversityClaytonAustralia
  4. 4.Stem Cell MedicineO’Brien InstituteMelbourneAustralia

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