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Cell and Tissue Research

, Volume 335, Issue 1, pp 5–16 | Cite as

Arterial versus venous endothelial cells

  • Nathaniel G. dela PazEmail author
  • Patricia A. D’Amore
Review

Abstract

Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect the arterial and venous systems. Because these two major conducting systems of the cardiovasculature differ functionally, it is not surprising that the physical makeup of arteries and veins, including the ECs that line their lumina, are also distinct. Although few would argue that the local environment contributes to the differences between arteries and veins, recent evidence has shown that the specification of arterial and venous identity is largely genetically determined.

Keywords

Vascular endothelial cells Specification ephrinB2 EphB4 VEGF Notch 

Notes

Acknowledgements

We thank Mr. Peter Mallen for the artwork, Dr. Eric Finkelstein for Fig. 2, and Ms. Christine Bagley for her editorial assistance.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Nathaniel G. dela Paz
    • 1
  • Patricia A. D’Amore
    • 1
  1. 1.Schepens Eye Research Institute and Harvard Medical SchoolBostonUSA

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