Cell and Tissue Research

, Volume 335, Issue 1, pp 271–281 | Cite as

Molecular heterogeneity of tumor endothelium

  • William C. AirdEmail author


Tumors depend on a vascular supply for their growth. Tumor blood vessels, which are derived from normal tissue vasculature, display a markedly abnormal phenotype. Tumor endothelial properties are highly varied in space and time. An important goal is to delineate the range of phenotypes in tumor endothelium and to identify tumor endothelial-specific molecular signatures. This information should lead to a more complete understanding of the mechanisms of tumor growth, the discovery of new therapeutic targets, and the development of biomarkers for diagnosis and surveillance. The goals of this review are to outline recent advances in dissecting tumor endothelial-cell-specific gene expression, to address mechanisms of phenotypic heterogeneity in tumor vascular beds, and to discuss the therapeutic implications of these findings.


Tumor Endothelial cells Heterogeneity Vascular biology Phage display 



The author thanks Steven Moskowitz for his artwork and Marianne Grant for her help with formatting. This work was supported by NIH grant HL076540.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.The Center for Vascular Biology Research and the Division of Molecular and Vascular MedicineBeth Israel Deaconess Medical Center/Harvard Medical SchoolBostonUSA

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