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Cell and Tissue Research

, Volume 315, Issue 2, pp 243–247 | Cite as

Elimination by necrosis, not apoptosis, of embryonic extraocular muscles in the muscular dysgenesis mutant of the mouse

  • Peter Heimann
  • Thilo Kuschel
  • Harald Jockusch
Regular Article

Abstract

Muscular dysgenesis (mdg) in the mouse is a loss-of-function mutation of the skeletal muscle isoform of the voltage-sensor Ca2+ channel of skeletal muscle (DHP receptor alpha1 subunit, Cchl1a3, Chr1), which is essential for excitation-contraction coupling. Affected individuals (genotype mdg/mdg, phenotype MDG) are unable to breathe and die perinatally. We introduce here extraocular muscles in the study of MDG myopathy and show that, despite their developmental origin from head placodes, they are affected like trunk and limb muscles. MDG myotubes in situ are eliminated by necrosis, not apoptosis.

Keywords

Necrosis/apoptosis Calcium channel Slow T-tubular Muscular dysgenesis Extraocular muscles Mouse (mdg/mdg

Notes

Acknowledgements

We thank Sandra Heising for excellent technical help.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Developmental Biology and Molecular Pathology, W7Bielefeld UniversityBielefeldGermany

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