Cell and Tissue Research

, Volume 315, Issue 1, pp 1–14

Perturbations in brain monoamine systems during stress

  • Gabriele Flügge
  • Marja van Kampen
  • M. Janneke Mijnster
Review

DOI: 10.1007/s00441-003-0807-0

Cite this article as:
Flügge, G., van Kampen, M. & Mijnster, M.J. Cell Tissue Res (2004) 315: 1. doi:10.1007/s00441-003-0807-0

Abstract

Monoamines modulate the activity of many neurons and there is evidence that a balanced synthesis of central nervous monoamines is a prerequisite for normal brain functioning. Stress accelerates both release and turnover of brain monoamines and the resulting fluctuations in concentrations affect various parameters within neurotransmitter systems. Acute stress leads to only transient alterations in monoamine systems so that homeostasis can be restored, in contrast, chronic stress accompanied by repetitive and/or prolonged stimulation of monoaminergic neurons can induce a long-lasting imbalance in central nervous neurotransmitter systems. Accordingly, stress-induced changes in brain monoamine systems are suspected to contribute to psychiatric diseases such as depression. The present paper gives a short overview of stress effects on brain monoamines and their receptors.

Keywords

Monoamine Stress Depression Adrenergic receptor Noradrenaline 

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Gabriele Flügge
    • 1
  • Marja van Kampen
    • 1
    • 2
  • M. Janneke Mijnster
    • 1
    • 3
  1. 1.Clinical Neurobiology LaboratoryGerman Primate CenterGöttingenGermany
  2. 2.ICON Clinical Research GmbHLangenGermany
  3. 3.Department of Cell Biology, Section ElectronmicroscopyUniversity of GroningenThe Netherlands

Personalised recommendations