Cell and Tissue Research

, Volume 309, Issue 1, pp 89–98 | Cite as

Suprachiasmatic nucleus organization

  • Robert Y. Moore
  • Joan C. Speh
  • Rehana K. Leak


The suprachiasmatic nucleus (SCN) of the hypothalamus is a dominant circadian pacemaker in the mammalian brain controlling the rest-activity cycle and a series of physiological and endocrine functions to provide a foundation for the successful elaboration of adaptive sleep and waking behavior. The SCN is anatomically and functionally organized into two subdivisions: (1) a core that lies adjacent to the optic chiasm, comprises predominantly neurons producing vasoactive intestinal polypeptide (VIP) or gastrin-releasing peptide (GRP) colocalized with GABA and receives dense visual and midbrain raphe afferents, and (2) a shell that surrounds the core, contains a large population of arginine vasopressin (AVP)-producing neurons in its dorsomedial portion, and a smaller population of calretinin (CAR)-producing neurons dorsally and laterally, colocalized with GABA, and receives input from non-visual cortical and subcortical regions. In this paper, we present a detailed quantitative analysis of the organization of the SCN core and shell in the rat and place this in the context of the functional significance of the subdivisions in the circadian control of regulatory systems.

Circadian rhythms Hypothalamus Neuropeptides Regulatory system Suprachiasmatic nucleus 


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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Robert Y. Moore
    • 1
  • Joan C. Speh
    • 2
  • Rehana K. Leak
    • 3
  1. 1.Department of Neurology, University of PittsburghPittsburgh, PAUSA
  2. 2.Department of Psychiatry, University of PittsburghPittsburgh, PAUSA
  3. 3.Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USAPittsburgh, PAUSA

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