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Human Genetics

, Volume 106, Issue 1, pp 14–18 | Cite as

Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses

  • S. Eckenrode
  • M.P. Marron
  • R. Nicholls
  • M.C.K. Yang
  • J.J. Yang
  • L.C. Guida Fonseca
  • J.-X. She
Original Investigation

Abstract.

Previous studies have identified a susceptibility region for insulin-dependent (type 1) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P=0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.

Keywords

Diabetes Mellitus Candidate Gene Domain Protein Strong Linkage Polymorphic Marker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • S. Eckenrode
    • 1
  • M.P. Marron
    • 1
  • R. Nicholls
    • 3
  • M.C.K. Yang
    • 2
  • J.J. Yang
    • 2
  • L.C. Guida Fonseca
    • 3
  • J.-X. She
    • 1
  1. 1.Department of Pathology, Immunology and Laboratory Medicine, and Center for Mammalian Genetics, Box 100275, College of Medicine, University of Florida, Gainesville, FL 32610, USA
  2. 2.Department of Statistics, University of Florida, Gainesville, Fla., USA
  3. 3.Department of Genetics, School of Medicine, Case Western Reserve University, Ohio, USA

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