Human Genetics

, Volume 109, Issue 5, pp 521–525 | Cite as

Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population

  • Akatsuki Kokaze
  • Mamoru Ishikawa
  • Naomi Matsunaga
  • Masao Yoshida
  • Yasuko Sekine
  • Koji Teruya
  • Nobuo Takeda
  • Yu Sumiya
  • Yoshiko Uchida
  • Yutaka Takashima
Original Investigation

Abstract.

As one approach to exploring whether the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is associated with atherosclerosis, we genotyped 461 healthy Japanese individuals and studied the relationship of mt5178 A/C genotypes to serum lipid levels. Blood specimens were obtained after at least a 12-h fasting period from the subjects. The mt5178 A/C was genotyped by the polymerase chain reaction/restriction fragment length polymorphism method. The relative frequency of mt5178 A was 41.6% (192/461) and of mt5178 C was 58.4% (269/461). After adjustments for age and body mass index, the high-density lipoprotein cholesterol concentration in males carrying mt5178 A was significantly higher than that in males carrying mt5178 C (P=0.026). The tryglyceride (TG) concentration in females carrying mt5178 A was significantly lower than that in females carrying mt5178 C (P=0.012). This difference in the TG level between the two genotypes was more evident in postmenopausal females than in premenopausal females. Mt5178 A seems to have an antiatherogenic effect. This is the first genetic epidemiological report on the association of mt5178 A/C polymorphism with serum lipid levels in the Japanese population.

Keywords

Cholesterol Lipoprotein Cholesterol Cholesterol Concentration Japanese Population Blood Specimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Akatsuki Kokaze
    • 1
  • Mamoru Ishikawa
    • 1
  • Naomi Matsunaga
    • 1
  • Masao Yoshida
    • 1
  • Yasuko Sekine
    • 1
  • Koji Teruya
    • 2
  • Nobuo Takeda
    • 2
  • Yu Sumiya
    • 1
  • Yoshiko Uchida
    • 1
  • Yutaka Takashima
    • 1
  1. 1.Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181–8611, Japan
  2. 2.Department of Preventive Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, Japan

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