Human Genetics

, Volume 103, Issue 3, pp 328–333 | Cite as

A novel locus for Leber congenital amaurosis on chromosome 14q24

  • David W. Stockton
  • Richard Alan Lewis
  • Emad B. Abboud
  • A. Al-Rajhi
  • Monzer Jabak
  • Kent L. Anderson
  • J. R. Lupski
Original Investigation

Abstract

Leber congenital amaurosis (LCA) is a clinically and genetically heterogeneous autosomal recessive retinal dystrophy and the most common genetic cause of congenital visual impairment. We used a DNA pooling strategy comparing the genotypes of affected to unaffected control pools in a genome-wide search for identity-by-descent on a consanguineous Saudi Arabian LCA family. A shift to homozygosity was observed in the affected DNA pool compared with the control pool at linked markers D14S606 and D14S610. Genotyping of individual DNA samples from the entire pedigree for marker D14S74, closely linked to these loci, and several flanking markers confirmed linkage with a ZMAX=13.29 at θ=0.0. These data assign a third locus (LCA3) for LCA to chromosome 14q24. This locus and the previously identified loci are excluded for other Saudi Arabian pedigrees, both confirming that this clinical disorder is genetically heterogeneous and that additional LCA genes remain to be identified.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • David W. Stockton
    • 1
  • Richard Alan Lewis
    • 1
  • Emad B. Abboud
    • 2
  • A. Al-Rajhi
    • 2
  • Monzer Jabak
    • 2
  • Kent L. Anderson
    • 1
  • J. R. Lupski
    • 1
  1. 1.Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 609 E, Houston, TX 77030–3498, USA e-mail: jlupski@bcm.tmc.edu, Tel.: +1 713 7986530, Fax: +1 713 7985073US
  2. 2.King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi ArabiaSA

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