MTHFR association with arteriosclerotic vascular disease?
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Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.
KeywordsCandidate Gene Vascular Disease Point Mutation Complex Disease Complex Phenotype
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