Advertisement

Human Genetics

, Volume 103, Issue 1, pp 11–21 | Cite as

MTHFR association with arteriosclerotic vascular disease?

  • Olivia Fletcher
  • A. M. Kessling
Review Article

Abstract

Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.

Keywords

Candidate Gene Vascular Disease Point Mutation Complex Disease Complex Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Olivia Fletcher
    • 1
  • A. M. Kessling
    • 1
  1. 1.Medical and Community Genetics, Imperial College School of Medicine, Kennedy Galton Centre, Level 8 V, Northwick Park and St. Mark’s NHS Trust, Watford Road, Harrow HA1 3UJ, UK Fax: +44 181 869 3167GB

Personalised recommendations