Human Genetics

, Volume 99, Issue 3, pp 295–297 | Cite as

The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p

  • Jaakko Kaukonen
  • Leena Alanen-Kurki
  • Markku Jalkanen
  • A. Palotie
Original investigation

Abstract

The chromosomal locations of the human and mouse syndecan genes have been shown to associate with the corresponding locations of members of the myc gene family, proto-oncogenes that code for transcription factors. Here, we demonstrate the precise localization and order of the human syndecan-1 and N-myc genes using fluorescence in situ hybridization techniques that provide different levels of resolution. By visualizing the actual centromere-telomere orientation of these two genes, the human syndecan-1 gene is localized to 2p23–24, just centromeric to the N-myc gene at 2p24.1.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Jaakko Kaukonen
    • 1
  • Leena Alanen-Kurki
    • 2
  • Markku Jalkanen
    • 2
  • A. Palotie
    • 1
  1. 1.Department of Clinical Medicine, University of Helsinki and the Laboratory Department of the Helsinki University Central Hospital, Haarmaninkatu 4, FIN-00290 Helsinki, FinlandFI
  2. 2.Turku Center for Biotechnology, Tykistokatu 6, BioCity, P.O. Box 123, FIN-20520 Turku, FinlandFI

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