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Human Genetics

, Volume 99, Issue 2, pp 233–236 | Cite as

Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12–q13.1 between PLCG1 and D20S17

  • Alexandros Argyrokastritis
  • Smaragda Kamakari
  • Manuela Kapsetaki
  • Aristidis Kritis
  • Iannis Talianidis
  • N. K. Moschonas
Original investigation

Abstract

Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNAs corresponding to various HNF-4 isoforms have been recently characterised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12–q13.1 between PLCG1 and D20S17 by genetic linkage analysis, taking advantage of an adjacent PstI restriction fragment length polymorphism, (RFLP), and by fluorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a region syntenic with mouse chromosome 2 where the hnf-4 homologue has been assigned.

Keywords

Transcription Factor Hormone Receptor Restriction Fragment Length Polymorphism Fragment Length Polymorphism Linkage Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Alexandros Argyrokastritis
    • 1
  • Smaragda Kamakari
    • 1
  • Manuela Kapsetaki
    • 1
  • Aristidis Kritis
    • 1
  • Iannis Talianidis
    • 1
  • N. K. Moschonas
    • 1
  1. 1.Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, P.O. Box 1527, GR-711 10 Heraklion, Greece Tel.: +30-81-212-469; Fax: 30-81-239-155 e-mail: moschon@victor.imbb.forth.grGR

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