Advertisement

Human Genetics

, Volume 98, Issue 3, pp 345–347 | Cite as

Prevalence of α-thalassemias in northern Thailand

  • M. Lemmens-Zygulska
  • A. Eigel
  • B. Helbig
  • T. Sanguansermsri
  • J. Horst
  • G. Flatz
Original investigation

Abstract

The population of northern Thailand has one of the highest frequencies of α-thalassemia in the world. However, the available distributional data are controversial. In addition to deletional types of α-thalassemia Hb, type Constant Spring should also be taken into consideration in α-thalassemia population studies, because it causes clinical α-thalassemia in the homozygous state or when present with both α-globin genes deleted in trans. We have examined a sample of 215 healthy subjects from four rural districts of Chiang Mai province. Out of these, 77 exhibited anomalies of the α-globin genes (αα/-α3.7 in 36; -α3.7/-α3.7 in 3; ––SEA in 30; αα/αCSα in 5; αααanti3.7 in 3). Therefore, no fewer than 2% of the children in northern Thailand are expected to be born with HbH disease or thalassemic hydrops fetalis. The considerable public health problem of hemoglobinopaties and the increasing acceptance of family planning necessitates facilities for the pre- and postnatal diagnosis of these disorders at the DNA level.

Keywords

Public Health Health Problem Healthy Subject Family Planning Distributional Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. Lemmens-Zygulska
    • 1
  • A. Eigel
    • 1
  • B. Helbig
    • 1
  • T. Sanguansermsri
    • 2
  • J. Horst
    • 1
  • G. Flatz
    • 3
  1. 1.Institut für Humangenetik der Westfälischen Wilhelms-Universität Münster, Vesaliusweg 12-14, D-48149 Münster, Germany Tel.: +49-251-835401; Fax: +49-251-835431DE
  2. 2.Chiang Mai University, Human Genetics Unit, Faculty of Medicine, Chiang Mai, 50002 ThailandTH
  3. 3.Medizinische Hochschule, Konstanty-Gutschow-Str. 8, D-30625 Hannover, GermanyDE

Personalised recommendations