Advertisement

Human Genetics

, Volume 108, Issue 1, pp 1–13 | Cite as

The human olfactory subgenome: from sequence to structure and evolution

  • Tania Fuchs
  • Gustavo Glusman
  • Shirley Horn-Saban
  • Doron Lancet
  • Yitzhak Pilpel
Original Investigation

Abstract.

Olfactory receptors (ORs) constitute the largest multigene family in multicellular organisms. Their evolutionary proliferation has been driven by the need to provide recognition capacity for millions of potential odorants with arbitrary chemical configurations. Human genome sequencing has provided a highly informative picture of the "olfactory subgenome", the repertoire of OR genes. We describe here an analysis of 224 human OR genes, a much larger number than hitherto systematically analyzed. These are derived by literature survey, data mining at 14 genomic clusters, and by an OR-targeted experimental sequencing strategy. The presented set contains at least 53% pseudogenes and is minimally divided into 11 gene families. One of these (no. 7) has undergone a particularly extensive expansion in primates. The analysis of this collection leads to insight into the origin of OR genes, suggesting a graded expansion through mammalian evolution. It also allows us to delineate a structural map of the respective proteins. A sequence database and analysis package is provided (http://bioinformatics.weizmann.ac.il/HORDE), which will be useful for analyzing human OR sequences genome-wide.

Keywords

Literature Survey Olfactory Receptor Multigene Family Multicellular Organism Mammalian Evolution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Tania Fuchs
    • 1
  • Gustavo Glusman
    • 1
  • Shirley Horn-Saban
    • 1
  • Doron Lancet
    • 1
  • Yitzhak Pilpel
    • 1
  1. 1.Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel

Personalised recommendations