Human Genetics

, Volume 107, Issue 3, pp 210–215 | Cite as

Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study

  • Wen-Harn Pan
  • Jaw-Wen Chen
  • Cathy Fann
  • Yuh-Shan Jou
  • Sheng-Yeu Wu
Original Investigation

Abstract.

A genetic linkage study of young-onset hypertension was performed on data from 59 nucleus families of Han Chinese residing in Taiwan. Thirty seven microsatellite markers near 18 hypertension candidate genes were genotyped. In a nonparametric identity-by-descent sibpair analysis, a positive linkage signal (defined as P<0.05) was found for four microsatellite markers, viz., D1S1612 (P=0.0162), D1S547 (P=0.0263), D8S1145 (P=0.0284), and D17S2193 (P=0.0256), which were located near genes for atrial natriuretic peptide (NPPA)/glucose transporter 5 (SLC2A5), angiotensinogen (AGT), lipoprotein lipase (LPL), and angiotensin-conveting enzyme (DCP1), respectively. Marker D5S1480 located near beta-2-adrenergic receptor (ADRB2) had a borderline P value (P=0.0785) for the positive signal. Comprehensive genotyping with further markers in these regions is underway to confirm whether these genes are linked to young-onset hypertension.

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Wen-Harn Pan
    • 1
  • Jaw-Wen Chen
    • 2
  • Cathy Fann
    • 1
  • Yuh-Shan Jou
    • 3
  • Sheng-Yeu Wu
    • 1
  1. 1.Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
  2. 2.Department of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan
  3. 3.Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei, Taiwan

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