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Statistical learning approaches in the genetic epidemiology of complex diseases

  • Anne-Laure BoulesteixEmail author
  • Marvin N. Wright
  • Sabine Hoffmann
  • Inke R. König
Original Investigation
Part of the following topical collections:
  1. Genetic epidemiology of complex diseases

Abstract

In this paper, we give an overview of methodological issues related to the use of statistical learning approaches when analyzing high-dimensional genetic data. The focus is set on regression models and machine learning algorithms taking genetic variables as input and returning a classification or a prediction for the target variable of interest; for example, the present or future disease status, or the future course of a disease. After briefly explaining the basic motivation and principle of these methods, we review different procedures that can be used to evaluate the accuracy of the obtained models and discuss common flaws that may lead to over-optimistic conclusions with respect to their prediction performance and usefulness.

Keywords

Regression Validation Cross-validation Omics data High-dimensional data Prognostic model 

Notes

Acknowledgements

We thank Jenny Lee for proofreading the manuscript.

Supplementary material

439_2019_1996_MOESM1_ESM.docx (25 kb)
Supplementary material 1 (docx 24 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute for Medical Information Processing, Biometry and EpidemiologyLudwig-Maximilians-UniversityMunichGermany
  2. 2.Leibniz Institute for Prevention Research and Epidemiology-BIPSBremenGermany
  3. 3.Section of Biostatistics, Department of Public HealthUniversity of CopenhagenCopenhagenDenmark
  4. 4.Institute of Medical Biometry and StatisticsUniversity of LübeckLübeckGermany

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