Human Genetics

, Volume 132, Issue 11, pp 1275–1285 | Cite as

Common genetic variants associated with lipid profiles in a Chinese pediatric population

  • Yue Shen
  • Bo Xi
  • Xiaoyuan Zhao
  • Hong Cheng
  • Dongqing Hou
  • Lijun Wu
  • Xingyu WangEmail author
  • Jie MiEmail author
Original Investigation


Genome-wide association (GWA) studies have identified many candidate genes that are associated with blood lipid and lipoprotein concentrations. In this study, we want to know whether the results from European for lipid-related single-nucleotide polymorphisms (SNPs) are generalizable to Chinese children. We genotyped seven SNPs in Chinese school-age children (n = 3,503) and assessed the associations of these SNPs with lipids profiles and dyslipidemia. After false discovery rate correction, of the seven SNPs, six (rs2144300, p ~ 9.30 × 10−3; rs1260333, p ~ 6.20 × 10−11; rs1260326, p ~ 8.73 × 10−11; rs10105606, p ~ 0.010; rs1748195, p ~ 0.016 and rs964184, p ~ 2.33 × 10−13) showed strong association with triglycerides. Three SNPs (rs1260333, p ~ 3.30 × 10−3; rs1260326, p ~ 4.39 × 10−3 and rs2954029, p ~ 6.36 × 10−4) showed strong association with total cholesterol. Two SNPs (rs10105606, p ~ 6.66 × 10−4 and rs1748195, p ~ 2.55 × 10−3) showed strong association with high density lipoprotein cholesterol. Four SNPs (rs1260333, p ~ 0.017; rs1260326, p ~ 0.013; rs2954029, p ~ 1.09 × 10−3 and rs964184, p ~ 5.51 × 10−3) showed strong association with low density lipoprotein cholesterol. There were significant associations between rs1260333 (OR is 0.82, 95 % CI 0.74–0.92, p ~ 3.96 × 10−4), rs1260326 (OR is 0.82, 95 % CI 0.74–0.92, p ~ 5.31 × 10−4), and rs964184 (OR is 1.36, 95 % CI 1.20–1.55, p ~ 1.89 × 10−6) and dyslipidemia. These SNPs generated strong combined effects on lipid profiles and dyslipidemia. Our study demonstrates that SNPs associated with lipids from European GWA studies also play roles in Chinese children, which broadened the understanding of lipids metabolism.


High Density Lipoprotein Cholesterol Risk Allele Chinese Child High Density Lipoprotein Cholesterol Level False Discovery Rate Correction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Polypeptide N-acetyl galactosaminyl transferase 2


Glucokinase (hexokinase 4) regulator


Lipoprotein lipase


Tribbles homolog 1 (Drosophila)


Angiopoietin-like 3


Minor allele frequency


Body mass index


Odds ratio


Confidence interval



We gratefully acknowledge the contributions of the data collection team and the individuals who participated in this study, both children and adults. We thank Zhang Meixian (Department of Epidemiology, Capital Institute of Pediatrics, Beijing), Liu Xin (Beijing Hypertension League Institute) and Zhang Yongzhi (Shantou University Medical College) for technical assistance. This work was supported by the National Basic Research Program (973 Program) of China (2013CB530605), National “Twelfth Five-Year” Plan for Science and Technology Support Program (2012BAI03B03), Beijing Key Science and Technology Program (D111100000611002), Beijing Health System Leading Talent Grant (2009-1-08).

Supplementary material

439_2013_1332_MOESM1_ESM.doc (502 kb)
Supplementary material 1 (DOC 501 kb)


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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Graduate School of Peking Union Medicine CollegeBeijingChina
  2. 2.Institute of Maternal and Child Health Care, School of Public HealthShandong UniversityJinanChina
  3. 3.Department of EpidemiologyCapital Institute of PediatricsBeijingChina
  4. 4.Laboratory of Human GeneticsBeijing Hypertension League InstituteBeijingChina

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