Human Genetics

, Volume 132, Issue 1, pp 1–4 | Cite as

Familial prostate cancer and HOXB13 founder mutations: geographic and racial/ethnic variations

Editorial
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References

  1. Akbari MR, Trachtenberg J, Lee J, Tam S, Bristow R, Loblaw A, Narod SA, Nam RK (2012) Association between germline HOXB13 G84E mutation and risk of prostate cancer. J Natl Cancer Inst 104: 1260–1262Google Scholar
  2. Choi M, Scholl UI, Ji W, Tikhonova IR, Zumbo P, Nayir A, Bakkaloglu A, Özen S, Sanjad S, Nelson-Williams C, Farhi A, Mane S (2009) Genetic diagnosis by whole exome capture and massively parallel DNA sequencing. Proc Natl Acad Sci USA 106:19096–19101PubMedCrossRefGoogle Scholar
  3. Cooper DN, Krawczak M, Antonorakis SE (1995) The nature and mechanisms of human gene mutation. In: Scriver C, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, 7th edn. McGraw-Hill, New York, pp 259–291Google Scholar
  4. Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng L, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA (2012) Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med 366:141–149PubMedCrossRefGoogle Scholar
  5. Gao X, Zacharek A, Grignon DJ, Sakr W, Powell IJ, Porter AT, Honn KV (1995) Localization of potential tumor suppressor loci to a <2 Mb region on chromosome 17q in human prostate cancer. Oncogene 11:1241–1247PubMedGoogle Scholar
  6. Gillanders EM, Xu J, Chang B-L, Lange EM, Wiklund F, Bailey-Wilson JE, Baffoe-Bonnie A, Jones M, Gildea D, Riedesel E, Albertus J, Isaacs SD, Wiley KE, Mohai CE, Matikainen MP, Tammela TLJ, Zheng SL, Brown WM, Rökman A, Carpten JD, Meyers DA, Walsh PC, Schleutker J, Gronberg H, Cooney KA, Isaacs WB, Trent JM (2004) Combined genome-wide scan for prostate cancer susceptibility genes. J Natl Cancer Inst 96:1240–1247PubMedCrossRefGoogle Scholar
  7. Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, Fennell T, Giannoukos G, Fisher S, Russ C, Gabriel S, Jaffe DB, Lander ES, Nusbaum C (2009) Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat Biotechnol 27:182–189PubMedCrossRefGoogle Scholar
  8. Hellebrand H, Sutter C, Honisch E, Gross E, Wappenschmidt B, Schem C, Deissler H, Ditsch N, Gress V, Kiechle M, Bartram CR, Schmutzler RK, Niederacher D, Arnold N, Meindl A (2011) Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. Hum Mutat 32:E2176–E2188PubMedCrossRefGoogle Scholar
  9. Karlsson R, Aly M, Clements M, Zheng L, Adolfsson J, Xu J, Grönberg H, Wiklund F (2012) A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. Eur Urol. doi:  10.1016/j.eururo.2012.07.027
  10. Lange EM, Gillanders EM, Davis CC, Brown WM, Campbell JK, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D, Markey C, Giri V, Dimmer JB, Montie JE, Trent JM, Cooney KA (2003) Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan Prostate Cancer Genetics Project finds evidence for linkage on chromosome 17 near BRCA1. Prostate 57:326–334PubMedCrossRefGoogle Scholar
  11. Lange EM, Robbins CM, Gillanders EM, Zheng SL, Xu J, Wang Y, White KA, Chang B-L, Ho LA, Trent JM, Carpten JD, Isaacs WB, Cooney KA (2007) Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis. Hum Genet 121:49–55PubMedCrossRefGoogle Scholar
  12. Lin X, Qu L, Chen Z, Xu C, Ye D, Shao Q, Wang X, Qi J, Chen Z, Zhou F, Wang M, Wang Z, He D, Wu D, Gao X, Yuan J, Wang G, Xu Y, Wang G, Dong P, Jiao Y, Yang J, Ou-Yang J, Jiang H, Zhu Y, Turner AR, Tao S, Na R, Ding Q, Lu D, Shi R, Sun J, Liu F, Zheng SL, Mo Z, Sun Y, Xu J (2012) A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men. Prostate. doi:  10.1002/pros.22552
  13. Maher B (2009) Exome-sequencing takes centre stage in cancer profiling. Nature 459:146–147PubMedCrossRefGoogle Scholar
  14. Ng SB, Turner EH, Robertson PD, Flygare SD, Bigham AW, Lee C, Shaffer T, Wong M, Bhattacharjee A, Eichler EE, Bamshad M et al (2009) Targeted capture and massively parallel sequencing of 12 human exomes. Nature 461:272–276PubMedCrossRefGoogle Scholar
  15. Thompson ER, Boyle SE, Johnson J, Ryland GL, Sawyer S, Choong DY, kConFab, Chenevix-Trench G, Trainer AH, Lindeman GJ, Mitchell G, James PA, Campbell IG (2012) Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. Hum Mutat 33:95–99PubMedCrossRefGoogle Scholar
  16. Williams BJ, Jones E, Zhu XL, Steele MR, Stephenson RA, Rohr LR, Brothman AR (1996) Evidence for a tumor suppressor gene distal to BRCA1 in prostate cancer. J Urol 155:720–725PubMedCrossRefGoogle Scholar
  17. Xu J, Lange E, Lu L, Zheng S, Zhong W, Thibodeau S, Cannon-Albright L, Camp N, Ray A, Stanford JL, Wiley K, Isaacs S, Walsh P, Naier C, Vogel W, Schleutker J, Luedeke M, Wahlfors T, Tammela T, Schaid D, McDonnell S, DeRycke M, Cancel-Tassin G, Cussenot O, Wiklund F, Gronberg H, Eeles R, Easton D, Kote-Jarai Z, Whittemore A, Hsieh C-L, Giles G, Hopper J, Gianluca S, Catalona W, Mandal D, Ledet E, Foulkes W, Hamel N, Maehle L, Moller P, Isaac P, Bailey-Wilson J, Carpten JD, Seminara D, Cooney K (2012) HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet. doi: 10.1007/s00439-012-1229-4

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Preventive Medicine and Public HealthCreighton UniversityOmahaUSA

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