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Human Genetics

, Volume 131, Issue 7, pp 1197–1203 | Cite as

Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

  • H. Dean HosgoodIIIEmail author
  • Wen-Chang Wang
  • Yun-Chul Hong
  • Jiu-Cun Wang
  • Kexin Chen
  • I-Shou Chang
  • Chien-Jen Chen
  • Daru Lu
  • Zhihua Yin
  • Chen Wu
  • Wei Zheng
  • Biyun Qian
  • Jae Yong Park
  • Yeul Hong Kim
  • Nilanjan Chatterjee
  • Ying Chen
  • Gee-Chen Chang
  • Chin-Fu Hsiao
  • Meredith Yeager
  • Ying-Huang Tsai
  • Hu Wei
  • Young Tae Kim
  • Wei Wu
  • Zhenhong Zhao
  • Wong-Ho Chow
  • Xiaoling Zhu
  • Yen-Li Lo
  • Sook Whan Sung
  • Kuan-Yu Chen
  • Jeff Yuenger
  • Joo Hyun Kim
  • Liming Huang
  • Ying-Hsiang Chen
  • Yu-Tang Gao
  • Jin Hee Kim
  • Ming-Shyan Huang
  • Tae Hoon Jung
  • Neil Caporaso
  • Xueying Zhao
  • Zhang Huan
  • Dianke Yu
  • Chang Ho Kim
  • Wu-Chou Su
  • Xiao-Ou Shu
  • In-San Kim
  • Bryan Bassig
  • Yuh-Min Chen
  • Sung Ick Cha
  • Wen Tan
  • Hongyan Chen
  • Tsung-Ying Yang
  • Jae Sook Sung
  • Chih-Liang Wang
  • Xuelian Li
  • Kyong Hwa Park
  • Chong-Jen Yu
  • Jeong-Seon Ryu
  • Yongbing Xiang
  • Amy Hutchinson
  • Jun Suk Kim
  • Qiuyin Cai
  • Maria Teresa Landi
  • Kyoung-Mu Lee
  • Jen-Yu Hung
  • Ju-Yeon Park
  • Margaret Tucker
  • Chien-Chung Lin
  • Yangwu Ren
  • Reury-Perng Perng
  • Chih-Yi Chen
  • Li Jin
  • Kun-Chieh Chen
  • Yao-Jen Li
  • Yu-Fang Chiu
  • Fang-Yu Tsai
  • Pan-Chyr Yang
  • Joseph F. FraumeniJr.
  • Adeline Seow
  • Dongxin Lin
  • Baosen Zhou
  • Stephen Chanock
  • Chao Agnes Hsiung
  • Nathaniel Rothman
  • Qing Lan
Original Investigation

Abstract

A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10−12); however, this association did not achieve genome-wide significance (p ≤ 10−7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10−8; allelic risk = 0.80, 95% confidence interval (CI) = 0.74–0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67–0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.

Keywords

Lung Adenocarcinoma Allelic Risk Lung Cancer Risk Lung Cancer Study TP63 Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflicts of interest

The authors have no conflicts of interest to report.

Supplementary material

439_2012_1144_MOESM1_ESM.xls (77 kb)
Supplementary material 1 (XLS 77 kb)

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Copyright information

© Springer-Verlag (outside the USA) 2012

Authors and Affiliations

  • H. Dean HosgoodIII
    • 1
    Email author
  • Wen-Chang Wang
    • 2
  • Yun-Chul Hong
    • 3
    • 4
  • Jiu-Cun Wang
    • 5
  • Kexin Chen
    • 6
  • I-Shou Chang
    • 7
  • Chien-Jen Chen
    • 8
    • 9
  • Daru Lu
    • 5
  • Zhihua Yin
    • 10
  • Chen Wu
    • 11
  • Wei Zheng
    • 12
  • Biyun Qian
    • 6
  • Jae Yong Park
    • 13
    • 14
    • 15
  • Yeul Hong Kim
    • 16
    • 17
    • 18
  • Nilanjan Chatterjee
    • 1
  • Ying Chen
    • 19
  • Gee-Chen Chang
    • 20
    • 21
    • 22
    • 36
  • Chin-Fu Hsiao
    • 2
  • Meredith Yeager
    • 1
    • 23
  • Ying-Huang Tsai
    • 24
    • 25
  • Hu Wei
    • 1
  • Young Tae Kim
    • 26
    • 27
  • Wei Wu
    • 10
  • Zhenhong Zhao
    • 5
  • Wong-Ho Chow
    • 1
  • Xiaoling Zhu
    • 6
  • Yen-Li Lo
    • 2
  • Sook Whan Sung
    • 28
    • 29
  • Kuan-Yu Chen
    • 30
  • Jeff Yuenger
    • 1
    • 23
  • Joo Hyun Kim
    • 27
  • Liming Huang
    • 11
  • Ying-Hsiang Chen
    • 2
  • Yu-Tang Gao
    • 31
  • Jin Hee Kim
    • 3
    • 4
  • Ming-Shyan Huang
    • 32
    • 33
  • Tae Hoon Jung
    • 13
  • Neil Caporaso
    • 1
  • Xueying Zhao
    • 5
  • Zhang Huan
    • 6
  • Dianke Yu
    • 11
  • Chang Ho Kim
    • 13
  • Wu-Chou Su
    • 34
  • Xiao-Ou Shu
    • 12
  • In-San Kim
    • 14
  • Bryan Bassig
    • 1
  • Yuh-Min Chen
    • 35
    • 36
  • Sung Ick Cha
    • 13
  • Wen Tan
    • 11
  • Hongyan Chen
    • 5
  • Tsung-Ying Yang
    • 20
  • Jae Sook Sung
    • 16
    • 17
  • Chih-Liang Wang
    • 24
  • Xuelian Li
    • 10
  • Kyong Hwa Park
    • 16
    • 18
  • Chong-Jen Yu
    • 30
  • Jeong-Seon Ryu
    • 37
  • Yongbing Xiang
    • 31
  • Amy Hutchinson
    • 1
    • 23
  • Jun Suk Kim
    • 16
    • 17
    • 18
  • Qiuyin Cai
    • 12
  • Maria Teresa Landi
    • 1
  • Kyoung-Mu Lee
    • 3
  • Jen-Yu Hung
    • 32
    • 33
  • Ju-Yeon Park
    • 26
  • Margaret Tucker
    • 1
  • Chien-Chung Lin
    • 34
  • Yangwu Ren
    • 10
  • Reury-Perng Perng
    • 35
  • Chih-Yi Chen
    • 38
  • Li Jin
    • 5
  • Kun-Chieh Chen
    • 20
  • Yao-Jen Li
    • 9
  • Yu-Fang Chiu
    • 2
  • Fang-Yu Tsai
    • 7
  • Pan-Chyr Yang
    • 30
  • Joseph F. FraumeniJr.
    • 1
  • Adeline Seow
    • 19
  • Dongxin Lin
    • 11
  • Baosen Zhou
    • 10
  • Stephen Chanock
    • 1
    • 23
  • Chao Agnes Hsiung
    • 2
  • Nathaniel Rothman
    • 1
  • Qing Lan
    • 1
  1. 1.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  2. 2.Division of Biostatistics and Bioinformatics, Institute of Population Health SciencesNational Health Research InstitutesZhunanTaiwan
  3. 3.Department of Preventive MedicineSeoul National University College of MedicineSeoulRepublic of Korea
  4. 4.Institute of Environmental Medicine, Seoul National University Medical Research CenterSeoulRepublic of Korea
  5. 5.Ministry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan UniversityShanghaiChina
  6. 6.Department of Epidemiology and BiostatisticsTianjin Medical University Cancer Hospital and InstituteTianjinPeople’s Republic of China
  7. 7.National Institute of Cancer Research, National Health Research InstitutesZhunanTaiwan
  8. 8.Genomics Research Center, Academia SinicaTaipeiTaiwan
  9. 9.Graduate Institute of Epidemiology, College of Public Health, National Taiwan UniversityTaipeiTaiwan
  10. 10.Department of Epidemiology, School of Public HealthChina Medical UniversityShenyangPeople’s Republic of China
  11. 11.Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina
  12. 12.Department of MedicineVanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt University School of MedicineNashvilleUSA
  13. 13.Department of Internal Medicine, School of MedicineKyungpook National UniversityDaeguRepublic of Korea
  14. 14.Department of Biochemistry, School of MedicineKyungpook National UniversityDaeguRepublic of Korea
  15. 15.Cancer Research Center, Kyungpook National University HospitalDaeguRepublic of Korea
  16. 16.Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam HospitalSeoulRepublic of Korea
  17. 17.Division of Brain, Department of Internal MedicineKorea University College of MedicineSeoulRepublic of Korea
  18. 18.Division of Oncology/Hematology, Department of Internal MedicineKorea University College of MedicineSeoulRepublic of Korea
  19. 19.Department of Epidemiology and Public HealthNational University of SingaporeSingaporeSingapore
  20. 20.Division of Chest Medicine, Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan
  21. 21.Institute of Biomedical Sciences, National Chung-Hsing UniversityTaichungTaiwan
  22. 22.School of Medicine, China Medical UniversityTaichungTaiwan
  23. 23.Department of Health and Human ServicesCore Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of HealthFrederickUSA
  24. 24.Department of Pulmonary and Critical CareChang Gung Memorial HospitalChia YiTaiwan
  25. 25.Department of Respiratory CareChang Gung UniversityTaoyuanTaiwan
  26. 26.Cancer Research Institute, Seoul National University College of MedicineSeoulRepublic of Korea
  27. 27.Department of Thoracic and Cardiovascular SurgeryClinical Research Institute, Seoul National University HospitalSeoulRepublic of Korea
  28. 28.Department of Thoracic and Cardiovascular SurgerySeoul National University College of MedicineSeoulRepublic of Korea
  29. 29.Department of Thoracic and Cardiovascular SurgerySeoul National University Bundang HospitalGeongi-doRepublic of Korea
  30. 30.Department of Internal MedicineNational Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwan
  31. 31.Department of EpidemiologyShanghai Cancer InstituteShanghaiChina
  32. 32.School of Medicine, Kaohsiung Medical UniversityKaohsiungTaiwan
  33. 33.Department of Internal MedicineKaohsiung Medical University HospitalKaohsiungTaiwan
  34. 34.Department of Internal MedicineNational Cheng Kung University Hospital and College of MedicineTainanTaiwan
  35. 35.Chest DepartmentTaipei Veterans General HospitalTaipeiTaiwan
  36. 36.School of Medicine, National Yang-Ming UniversityTaipeiTaiwan
  37. 37.Department of Internal MedicineInha University College of MedicineIncheonRepublic of Korea
  38. 38.Cancer Center, China Medical University HospitalTaipeiTaiwan

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