Human Genetics

, Volume 128, Issue 4, pp 461–463 | Cite as

Identification of an autosomal recessive stuttering locus on chromosome 3q13.2–3q13.33

  • Muhammad Hashim Raza
  • Sheikh Riazuddin
  • Dennis Drayna
Short Report


Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2–3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.



We thank Ms. Bushra Raza for assistance with stuttering diagnosis, and the research subjects for their generous cooperation with this study.


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Copyright information

© US Government 2010

Authors and Affiliations

  • Muhammad Hashim Raza
    • 1
    • 2
  • Sheikh Riazuddin
    • 2
    • 3
  • Dennis Drayna
    • 1
    • 4
  1. 1.National Institute on Deafness and Other Communication Disorders, National Institutes of HealthBethesdaUSA
  2. 2.Center of Excellence in Molecular BiologyPunjab UniversityLahorePakistan
  3. 3.Allama Iqbal Medical CollegeLahorePakistan
  4. 4.NIDCD/NIHRockvilleUSA

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