Human Genetics

, Volume 127, Issue 4, pp 455–458

A genome-wide survey does not show the genetic distinctiveness of Basques

  • Hafid Laayouni
  • Francesc Calafell
  • Jaume Bertranpetit
Short Report

DOI: 10.1007/s00439-010-0798-3

Cite this article as:
Laayouni, H., Calafell, F. & Bertranpetit, J. Hum Genet (2010) 127: 455. doi:10.1007/s00439-010-0798-3

Abstract

Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that FST distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised.

Supplementary material

439_2010_798_MOESM1_ESM.doc (244 kb)
Supplementary material 1 (DOC 244 kb)

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Hafid Laayouni
    • 1
    • 2
  • Francesc Calafell
    • 1
    • 2
  • Jaume Bertranpetit
    • 1
    • 2
  1. 1.IBE, Institute of Evolutionary Biology (UPF-CSIC), CEXS-UPF-PRBBBarcelona, CataloniaSpain
  2. 2.Centro de Investigación Biomédica En Red, Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain

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