Human Genetics

, Volume 127, Issue 4, pp 453–454 | Cite as

Erratum to: Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging

  • Kristin K. Nicodemus
  • Joseph H. Callicott
  • Rachel G. Higier
  • Augustin Luna
  • Devon C. Nixon
  • Barbara K. Lipska
  • Radhakrishna Vakkalanka
  • Ina Giegling
  • Dan Rujescu
  • David St. Clair
  • Pierandrea Muglia
  • Yin Yao Shugart
  • Daniel R. Weinberger
Erratum

Erratum to: Hum Genet DOI 10.1007/s00439-009-0782-y

Authors regret that Figs. 2 and 3 labeling in the online published article, color indication for graph bars “Non-risk” and “Risk” were inadvertently swapped. The corrected figures are given below.
Fig. 2

CIT intragenic neuroimaging epistasis. CIT rs3847960 by CIT rs440299 interaction in normal subjects studied with BOLD fMRI during the N back working memory task. Figure at the top shows loci (in yellow) within brain in which significant interaction is found (p < 0.05 corrected) for all voxels within prefrontal cortical region of interest. Image at bottom shows relative degree of activation of DLPFC region showing imaging interaction based on genotypes at these two SNPs [fMRI signal extracted from maximum voxel and run as ANOVA in SPSS yielded F(1,256) = 9.960, p = 0.002]. The combination of both risk associated genotypes is disproportionally inefficient, i.e., have greatest activation without any difference in performance. Error bars represent 1 standard error of the mean. Frontal lobe (sub-gyral) mean activation extracted from 10 mm sphere at (30 37 8) Talairach

Fig. 3

DISC1 by CIT neuroimaging epistasis. DISC1 rs1411771 by CIT rs10744743 interaction in 217 normal subjects studied with BOLD fMRI during the N-back working memory task. The cross-sectional brain images at top figure show loci (in yellow) within brain showing a significant inefficiency effect associated with DISC1 risk × CIT risk SNPs (p < 0.05 small volume correction SVC). The graph at bottom compares a measure of fMRI activation during this task for each genotype combination extracted from right PFC yielding a significant epistatic interaction [fMRI signal extracted from maximum voxel and run as ANOVA in SPSS yielded F(1,213) = 5.3 p < 0.05]

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Kristin K. Nicodemus
    • 1
    • 2
    • 3
  • Joseph H. Callicott
    • 1
  • Rachel G. Higier
    • 1
  • Augustin Luna
    • 1
  • Devon C. Nixon
    • 1
  • Barbara K. Lipska
    • 1
  • Radhakrishna Vakkalanka
    • 1
  • Ina Giegling
    • 4
  • Dan Rujescu
    • 4
  • David St. Clair
    • 5
  • Pierandrea Muglia
    • 6
  • Yin Yao Shugart
    • 7
    • 8
  • Daniel R. Weinberger
    • 1
  1. 1.Genes, Cognition and Psychosis ProgramIntramural Research Program, National Institute of Mental Health, National Institutes of HealthBethesdaUSA
  2. 2.Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK
  3. 3.Department of Clinical Pharmacology, Old Road Campus Research BuildingUniversity of OxfordOxfordUK
  4. 4.Section of Molecular and Clinical Neurobiology, Department of PsychiatryLudwig Maximilians UniversityMunichGermany
  5. 5.Institute of Medical SciencesUniversity of AberdeenAberdeenUK
  6. 6.GlaxoSmithKlineVeronaItaly
  7. 7.Department of EpidemiologyJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  8. 8.Genomic Research Branch, Division of Neuroscience CenterNational Institute of Mental Health, National Institutes of HealthBethesdaUSA

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