Human Genetics

, Volume 125, Issue 5–6, pp 633–638 | Cite as

P53 polymorphism and lung cancer susceptibility: a pooled analysis of 32 case–control studies

  • Shengming Dai
  • Chen Mao
  • Lijun Jiang
  • Guisheng Wang
  • Hongge Cheng
Original Investigation

Abstract

To explore the real association between p53 codon 72 polymorphism and lung cancer risk, a pooled analysis of 32 case–control studies involving 19,255 subjects was conducted. When all 32 studies were pooled into the analysis, significantly elevated lung cancer risks were associated with variant genotypes in all genetic models (for Pro/Arg vs. Arg/Arg: OR 1.21, 95% CI 1.01–1.23; for Pro/Pro vs. Arg/Arg: OR 1.20, 95% CI 1.03–1.39; for Pro/Pro + Pro/Arg vs. Arg/Arg: OR 1.14, 95% CI 1.03–1.25; for Pro/Pro vs. Arg/Arg + Pro/Arg: OR 1.06, 95% CI 1.01–1.12). In the subgroup analysis by ethnicity, histological type, or smoking status, significantly increased risks were found in subgroups such as Asians, Caucasians, lung adenocarcinoma patients, or smokers, respectively. In conclusion, our results suggest that the Pro allele at p53 codon 72 is emerging as a low-penetrance susceptibility allele for lung cancer development.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Shengming Dai
    • 1
    • 2
  • Chen Mao
    • 3
  • Lijun Jiang
    • 1
  • Guisheng Wang
    • 1
  • Hongge Cheng
    • 1
  1. 1.Department of LabThe Fourth Hospital Affiliated to Guangxi Medical UniversityLiuzhouChina
  2. 2.Department of OncologyThe Fourth Hospital Affiliated to Guangxi Medical UniversityLiuzhouChina
  3. 3.Department of Epidemiology, School of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhouChina

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