Human Genetics

, Volume 125, Issue 5–6, pp 627–631

ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls

  • Hai-Feng Zhang
  • Li-Xin Qiu
  • Yu Chen
  • Wa-Li Zhu
  • Chen Mao
  • Li-Guang Zhu
  • Ming-Hua Zheng
  • Yan Wang
  • Lei Lei
  • Jian Shi
Original Investigation

DOI: 10.1007/s00439-009-0660-7

Cite this article as:
Zhang, HF., Qiu, LX., Chen, Y. et al. Hum Genet (2009) 125: 627. doi:10.1007/s00439-009-0660-7

Abstract

Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn’s disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians (P < 0.01). The pooled estimations of OR1 (GG vs. AA) and OR2 (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69–2.05] and (1.39, 95% CI 1.27–1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.

Supplementary material

439_2009_660_MOESM1_ESM.doc (89 kb)
Table 1 Main characteristics of the included studies (DOC 89 kb)

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hai-Feng Zhang
    • 1
  • Li-Xin Qiu
    • 2
  • Yu Chen
    • 3
  • Wa-Li Zhu
    • 1
  • Chen Mao
    • 4
  • Li-Guang Zhu
    • 1
  • Ming-Hua Zheng
    • 5
  • Yan Wang
    • 1
  • Lei Lei
    • 1
  • Jian Shi
    • 6
  1. 1.Department of CardiologyInstitute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical UniversityNanningChina
  2. 2.Department of Medical Oncology, Cancer Hospital, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.Department of Laboratory Medicine, Shanghai Changzheng HospitalSecond Military Medical UniversityShanghaiChina
  4. 4.Department of Epidemiology, School of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhouChina
  5. 5.Department of Infection and Liver DiseasesThe First Affiliated Hospital of Wenzhou Medical CollegeWenzhouChina
  6. 6.Department of Gastroenterology, Shanghai Changzheng HospitalSecond Military Medical UniversityShanghaiChina

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