Human Genetics

, Volume 125, Issue 5–6, pp 467–491 | Cite as

Molecular genetics of atherosclerosis

  • Himadri Roy
  • Shalini Bhardwaj
  • Seppo Yla-Herttuala
Review Article


Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic polymorphisms significantly influence susceptibility to atherosclerotic vascular diseases. A large number of candidate genes, genetic polymorphisms and susceptibility loci associated with atherosclerotic diseases have been identified in recent years and their number is rapidly increasing. In this review we focus on some of the major candidate genes and genetic polymorphisms associated with human atherosclerotic vascular diseases.



This study was supported by Finnish Academy, Finnish Foundation for Cardiovascular diseases, and EU lymphangiogenomics (LSHG-CT-2004-503573).


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Himadri Roy
    • 1
  • Shalini Bhardwaj
    • 1
  • Seppo Yla-Herttuala
    • 1
  1. 1.Department of Molecular Medicine and Biotechnology, A.I. Virtanen InstituteUniversity of KuopioKuopioFinland

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