Human Genetics

, Volume 125, Issue 2, pp 199–209 | Cite as

Population admixture associated with disease prevalence in the Boston Puerto Rican health study

  • Chao-Qiang LaiEmail author
  • Katherine L. Tucker
  • Shweta Choudhry
  • Laurence D. Parnell
  • Josiemer Mattei
  • Bibiana García-Bailo
  • Kenny Beckman
  • Esteban González Burchard
  • José M. Ordovás
Original Investigation


Older Puerto Ricans living in the continental U.S. suffer from higher rates of diabetes, obesity, cardiovascular disease and depression compared to non-Hispanic White populations. Complex diseases, such as these, are likely due to multiple, potentially interacting, genetic, environmental and social risk factors. Presumably, many of these environmental and genetic risk factors are contextual. We reasoned that racial background may modify some of these risk factors and be associated with health disparities among Puerto Ricans. The contemporary Puerto Rican population is genetically heterogeneous and originated from three ancestral populations: European settlers, native Taíno Indians, and West Africans. This rich-mixed ancestry of Puerto Ricans provides the intrinsic variability needed to untangle complex gene–environment interactions in disease susceptibility and severity. Herein, we determined whether a specific ancestral background was associated with either of four major disease outcomes (diabetes, obesity, cardiovascular disease, and depression). We estimated the genetic ancestry of 1,129 subjects from the Boston Puerto Rican Health Study based on genotypes of 100 ancestry informative markers (AIMs). We examined the effects of ancestry on tests of association between single AIMs and disease traits. The ancestral composition of this population was 57.2% European, 27.4% African, and 15.4% Native American. African ancestry was negatively associated with type 2 diabetes and cardiovascular disease, and positively correlated with hypertension. It is likely that the high prevalence rate of diabetes in Africans, Hispanics, and Native Americans is not due to genetic variation alone, but to the combined effects of genetic variation interacting with environmental and social factors.


Population Stratification Ancestral Population African Ancestry Total Household Income Population Admixture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by the National Institutes of Health, National Institute on Aging, Grant Number 5P01AG023394-02, NIH/NHLBI grant number HL54776 and HL078885 and contracts 53-K06-5-10 and 58–1950-9-001 from the U.S. Department of Agriculture Research Service.

Supplementary material

439_2008_612_MOESM1_ESM.xls (34 kb)
Supplementary material 1 (XLS 33 kb)


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Chao-Qiang Lai
    • 1
    Email author
  • Katherine L. Tucker
    • 2
  • Shweta Choudhry
    • 3
  • Laurence D. Parnell
    • 1
  • Josiemer Mattei
    • 1
  • Bibiana García-Bailo
    • 1
  • Kenny Beckman
    • 5
  • Esteban González Burchard
    • 3
    • 4
  • José M. Ordovás
    • 1
  1. 1.Nutrition and Genomics LaboratoryJM-USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA
  2. 2.Dietary Assessment and Epidemiology Research ProgramJM-USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA
  3. 3.Department of MedicineUniversity of CaliforniaSan FranciscoUSA
  4. 4.Department of Biopharmaceutical SciencesUniversity of CaliforniaSan FranciscoUSA
  5. 5.Functional Genomics CoreChildren’s Hospital Oakland Research InstituteOaklandUSA

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