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Human Genetics

, Volume 124, Issue 6, pp 669–675 | Cite as

A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2–q12.3

  • Arunima Chatterjee
  • Rajeev Jalvi
  • Nishtha Pandey
  • R. Rangasayee
  • Anuranjan Anand
Original Investigation

Abstract

Autosomal dominant nonsyndromic hearing loss (ADNSHL) accounts for about one-fifth of hereditary hearing loss in humans. In the present study, we have analyzed a three-generation family with 14 of its members manifesting ADNSHL, using a genome-wide linkage mapping approach. We found a novel locus DFNA59 between the D11S929 and D11S480 markers in the chromosome location 11p14.2–q12.3. The highest two-point lod score of 5.72 at recombination fraction = 0 was obtained for D11S4152, D11S4154, D11S1301, D11S905 and D11S1344. The critical genomic region comprising about 37 megabases of DNA is proposed to carry a gene for ADNSHL in the family. About 50 cochlear-expressed genes mapping to the region are strong candidates which we propose to examine to identify the gene responsible for the hearing impairment.

Keywords

Hearing Loss Genetic Interval Nonsyndromic Hearing Loss Hereditary Hearing Loss Protein Interaction Prediction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank the members of the family examined for participating in this study. This research was supported by JNCASR, Bangalore and a research grant from DBT, New Delhi. We thank Sharat Chandra for critical reading of the manuscript and helpful discussions.

Supplementary material

439_2008_596_MOESM1_ESM.doc (130 kb)
Supplementary Table 1 (DOC 129 kb)

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Arunima Chatterjee
    • 1
  • Rajeev Jalvi
    • 2
  • Nishtha Pandey
    • 1
  • R. Rangasayee
    • 2
  • Anuranjan Anand
    • 1
  1. 1.Molecular Biology and Genetics UnitJawaharlal Nehru Centre for Advanced Scientific ResearchBangaloreIndia
  2. 2.Ali Yavar Jung National Institute for the Hearing HandicappedMumbaiIndia

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