Human Genetics

, 125:1

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci

  • Shu-Feng Lei
  • Tie-Lin Yang
  • Li-Jun Tan
  • Xiang-Ding Chen
  • Yan Guo
  • Yan-Fang Guo
  • Liang Zhang
  • Xiao-Gang Liu
  • Han Yan
  • Feng Pan
  • Zhi-Xin Zhang
  • Yu-Mei Peng
  • Qi Zhou
  • Li-Na He
  • Xue-Zhen Zhu
  • Jing Cheng
  • Yao-Zhong Liu
  • Christopher J. Papasian
  • Hong-Wen Deng
Original Investigation

DOI: 10.1007/s00439-008-0590-9

Cite this article as:
Lei, SF., Yang, TL., Tan, LJ. et al. Hum Genet (2009) 125: 1. doi:10.1007/s00439-008-0590-9

Abstract

In Caucasian, several studies have identified some common variants associated with human stature variation. However, no such study was performed in Chinese, which is the largest population in the world and evidently differs from Caucasian in genetic background. To identify common or ethnic specific genes for stature in Chinese, an initial GWAS and follow-up replication study were performed. Our initial GWAS study found that a group of 13 contiguous SNPs, which span a region of ~150 kb containing two neighboring genes, zinc finger protein (ZNP) 510 and ZNP782, achieved strong signals for association with stature, with P values ranging from 9.71 × 10−5 to 3.11 × 10−6. After false discovery rate correction for multiple testing, 9 of the 13 SNPs remain significant (FDR q = 0.036−0.046). The follow-up replication study in an independent 2,953 unrelated southern Chinese confirmed the association of rs10816533 with stature (P = 0.029). All the13 SNPs were in consistently strong linkage disequilibrium (D′ > 0.99) and formed a single perfect haplotype block. The minor allele frequencies for the 13 contiguous SNPs have evidently ethnic difference, which range from 0.21 to 0.33 in Chinese but have as low as ~0.017 reported in dbSNP database in Caucasian. The present results suggest that the genomic region containing the ZNP510 and ZNP782 genes is an ethnic specific locus associated with stature variation in Chinese.

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Shu-Feng Lei
    • 1
    • 4
  • Tie-Lin Yang
    • 2
  • Li-Jun Tan
    • 1
  • Xiang-Ding Chen
    • 1
  • Yan Guo
    • 2
  • Yan-Fang Guo
    • 2
  • Liang Zhang
    • 3
  • Xiao-Gang Liu
    • 2
    • 4
  • Han Yan
    • 2
  • Feng Pan
    • 2
  • Zhi-Xin Zhang
    • 2
  • Yu-Mei Peng
    • 2
  • Qi Zhou
    • 2
  • Li-Na He
    • 2
  • Xue-Zhen Zhu
    • 2
  • Jing Cheng
    • 3
  • Yao-Zhong Liu
    • 4
  • Christopher J. Papasian
    • 4
  • Hong-Wen Deng
    • 1
    • 4
  1. 1.Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life SciencesHunan Normal UniversityChangshaPeople’s Republic of China
  2. 2.The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anPeople’s Republic of China
  3. 3.National Engineering Research Center for Beijing Biochip TechnologyBeijingPeople’s Republic of China
  4. 4.School of Medicine University of Missouri-Kansas CityKansas CityUSA

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