Human Genetics

, Volume 124, Issue 5, pp 553–555 | Cite as

MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe

  • Michal Vrablik
  • Richard Ceska
  • Vera Adamkova
  • Anne Peasey
  • Hynek Pikhart
  • Ruzena Kubinova
  • Michael Marmot
  • Martin Bobak
  • Jaroslav A. Hubacek
Short Report

Abstract

We tested the hypothesis that the MLXIPL rs3812316 variant predicts plasma triglyceride (TG) levels. We compared three groups of adult individuals: 162 persons with TG > 10 mmol/L, 266 persons with TG < 0.65 mmol/L, and 2,043 population-based controls (range of TG concentrations 0.7–8.7 mmol/L). We found a small difference in the frequency of the Gln allele carriers between population controls (20.4%) and persons with low TG (26.3%, P = 0.033). We found no difference between individuals with high TG and population controls, and there was no association between the MLXIPL variant and plasma TG levels among the population controls.

Notes

Acknowledgments

This work was supported by project No. 1M0510 from the Ministry of Health, Youth and Education of the Czech Republic; grant from Institute for Clinical and Experimental Medicine (00023001); grants from the Welcome Trust (Reference numbers 064947/Z/01/Z and 081081/Z/06/Z); the US National Institute on Aging (1R01 AG23522-01) and from the MacArthur Foundation.

References

  1. Cífková R, Skodová Z, Lánská V, Adámková V, Novozámská E, Petrzílková Z, Jozífová M, Plásková M, Hejl Z, Palous D, Galovcová M (2004) Trends in blood pressure levels, prevalence, awareness, treatment, and control of hypertension in the Czech population from 1985 to 2000/01. J Hypertens 22:1479–1485PubMedCrossRefGoogle Scholar
  2. Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, Wahlstrand B, Hedner T, Corella D, Tai ES, Ordovas JM, Berglund G, Vartiainen E, Jousilahti P, Hedblad B, Taskinen MR, Newton-Cheh C, Salomaa V, Peltonen L, Groop L, Altshuler DM, Orho-Melander M (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40:189–197PubMedCrossRefGoogle Scholar
  3. Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gómez Pérez FJ, Frazer KA, Elliott P, Scott J, Milos PM, Cox DR, Thompson JF (2008) Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 40:149–151PubMedCrossRefGoogle Scholar
  4. Ma L, Robinson LN, Towle HC (2006) ChREBP Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem 39:28721–28730CrossRefGoogle Scholar
  5. Peasey A, Bobak M, Kubinova R, Malyutina S, Pajak A, Tamosiunas A, Pikhart H, Nicholson A, Marmot M (2006) Determinants of cardiovascular disease and other non-communicable diseases in Central and Eastern Europe: rationale and design of the HAPIEE study. BMC Public Health 6:255PubMedCrossRefGoogle Scholar
  6. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, Boekholdt SM, Khaw KT, Gudnason V (2007) Triglycerides and the risk of coronary heart disease: 10 158 incident cases among 262 525 participants in 29 Western prospective studies. Circulation 115:450–458PubMedCrossRefGoogle Scholar
  7. Uyeda K, Repa JJ (2006) Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4:107–110PubMedCrossRefGoogle Scholar
  8. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR (2008) Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40:161–169PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Michal Vrablik
    • 1
  • Richard Ceska
    • 1
  • Vera Adamkova
    • 2
    • 3
  • Anne Peasey
    • 4
  • Hynek Pikhart
    • 4
  • Ruzena Kubinova
    • 5
  • Michael Marmot
    • 4
  • Martin Bobak
    • 4
  • Jaroslav A. Hubacek
    • 1
    • 2
    • 3
    • 6
    • 7
  1. 1.3rd Internal Department, 1st Medical FacultyCharles UniversityPragueCzech Republic
  2. 2.Institute for Clinical and Experimental MedicinePragueCzech Republic
  3. 3.Faculty of Public Health and Social StudiesSouth Bohemia UniversityCeske BudejoviceCzech Republic
  4. 4.Department of Epidemiology and Public HealthUniversity College LondonLondonUK
  5. 5.National Institute of Public HealthPragueCzech Republic
  6. 6.Cardiovascular Research CenterPragueCzech Republic
  7. 7.IKEM-LVAPrague 4Czech Republic

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