MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe
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We tested the hypothesis that the MLXIPL rs3812316 variant predicts plasma triglyceride (TG) levels. We compared three groups of adult individuals: 162 persons with TG > 10 mmol/L, 266 persons with TG < 0.65 mmol/L, and 2,043 population-based controls (range of TG concentrations 0.7–8.7 mmol/L). We found a small difference in the frequency of the Gln allele carriers between population controls (20.4%) and persons with low TG (26.3%, P = 0.033). We found no difference between individuals with high TG and population controls, and there was no association between the MLXIPL variant and plasma TG levels among the population controls.
This work was supported by project No. 1M0510 from the Ministry of Health, Youth and Education of the Czech Republic; grant from Institute for Clinical and Experimental Medicine (00023001); grants from the Welcome Trust (Reference numbers 064947/Z/01/Z and 081081/Z/06/Z); the US National Institute on Aging (1R01 AG23522-01) and from the MacArthur Foundation.
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