Human Genetics

, Volume 124, Issue 2, pp 179–185 | Cite as

A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia

  • Akihiro Fujimoto
  • Jun Ohashi
  • Nao Nishida
  • Taku Miyagawa
  • Yasuyuki Morishita
  • Tatsuhiko Tsunoda
  • Ryosuke Kimura
  • Katsushi Tokunaga
Original Investigations

Abstract

Hair morphology is a highly divergent phenotype among human populations. We recently reported that a nonsynonymous SNP in the ectodysplasin A receptor (EDAR 1540T/C) is associated with head hair fiber thickness in an ethnic group in Thailand (Thai-Mai) and an Indonesian population. However, these Southeast Asian populations are genetically and geographically close, and thus the genetic contribution of EDAR to hair morphological variation in the other Asian populations has remained unclear. In this study, we examined the association of 1540T/C with hair morphology in a Japanese population (Northeast Asian). As observed in our previous study, 1540T/C showed a significant association with hair cross-sectional area (P = 2.7 × 10−6) in Japanese. When all populations (Thai-Mai, Indonesian, and Japanese) were combined, the association of 1540T/C was stronger (P = 3.8 × 10−10) than those of age, sex, and population. These results indicate that EDAR is the genetic determinant of hair thickness as well as a strong contributor to hair fiber thickness variation among Asian populations.

Abbreviations

EDAR

Ectodysplasin A receptor

JPN

189 participants from Tokyo, Japan

THM

65 participants from Thai-Mai, in Thailand

IDN

121 participants from Indonesia

SEA

Southeast Asians (THM and IDN)

Supplementary material

439_2008_537_MOESM1_ESM.pdf (25 kb)
MOESM1 [Supplementary Tables S1 and S2] (PDF 24 kb)

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Akihiro Fujimoto
    • 2
    • 3
    • 1
  • Jun Ohashi
    • 2
    • 4
  • Nao Nishida
    • 2
  • Taku Miyagawa
    • 2
  • Yasuyuki Morishita
    • 5
  • Tatsuhiko Tsunoda
    • 3
  • Ryosuke Kimura
    • 6
  • Katsushi Tokunaga
    • 2
  1. 1.Data Analysis Fusion Team, Computational Science Research Program, RIKENTokyoJapan
  2. 2.Department of Human Genetics, Graduate School of MedicineThe University of TokyoTokyoJapan
  3. 3.Center for Genomic Medicine, RIKENYokohamaJapan
  4. 4.Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human SciencesUniversity of TsukubaTsukubaJapan
  5. 5.Department of Molecular Pathology, Graduate School of MedicineThe University of TokyoTokyoJapan
  6. 6.Department of Forensic MedicineTokai University School of MedicineIseharaJapan

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