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Human Genetics

, Volume 122, Issue 6, pp 605–614 | Cite as

Evidence for linkage of a new region (11p14) to eczema and allergic diseases

  • Michel Guilloud-Bataille
  • Emmanuelle Bouzigon
  • Isabella Annesi-Maesano
  • Jean Bousquet
  • Denis Charpin
  • Frédéric Gormand
  • Joëlle Hochez
  • Jocelyne Just
  • Arnaud Lemainque
  • Nicole Le Moual
  • Régis Matran
  • Françoise Neukirch
  • Marie-Pierre Oryszczyn
  • Evelyne Paty
  • Isabelle Pin
  • Daniel Vervloet
  • Francine Kauffmann
  • Mark Lathrop
  • Florence Demenais
  • Marie-Hélène DizierEmail author
Original Investigation

Abstract

Asthma, allergic rhinitis (AR) and atopic dermatitis also called eczema are allergic co-morbidites, which are likely to depend on pleiotropic genetic effects as well as on specific genetic factors. After a previous genome-wide linkage screen conducted for asthma and AR in a sample of 295 French EGEA families ascertained through asthmatic subjects, the aim here was to search for genetic factors involved in eczema and more particularly the ones shared by the three allergic diseases using the same EGEA data. In this sake, eczema and phenotypes of “allergic disease” accounting for the joint information on the presence/absence of the three diseases were examined by linkage analyses using the maximum likelihood binomial method. A fine mapping was carried out in regions detected for potential linkage, followed by association studies using the family-based association test (FBAT). Evidence for linkage to 11p14 region was shown for “allergic disease” and eczema. Linkage was also indicated between eczema and 5q13 and between “allergic disease” and both 5p15 and 17q21 regions. Fine mapping supported the evidence of linkage to 11p14 and FBAT analyses showed the association between “allergic disease” and a marker located at the linkage peak on 11p14. Further investigations in this region will allow identifying genetic factor(s) which could have pleiotropic effect in the three allergic diseases.

Keywords

Asthma Atopic Dermatitis Allergic Rhinitis Allergic Rhinitis Allergic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was partly supported by EU Framework Programme for Research, contract no. FOOD-CT-2004-506378, the GA2LEN project, Global Allergy and Asthma European Network.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Michel Guilloud-Bataille
    • 1
    • 2
  • Emmanuelle Bouzigon
    • 3
    • 4
  • Isabella Annesi-Maesano
    • 5
    • 6
  • Jean Bousquet
    • 7
  • Denis Charpin
    • 8
  • Frédéric Gormand
    • 9
  • Joëlle Hochez
    • 10
  • Jocelyne Just
    • 11
  • Arnaud Lemainque
    • 12
  • Nicole Le Moual
    • 13
  • Régis Matran
    • 14
  • Françoise Neukirch
    • 15
  • Marie-Pierre Oryszczyn
    • 13
  • Evelyne Paty
    • 16
  • Isabelle Pin
    • 17
  • Daniel Vervloet
    • 18
  • Francine Kauffmann
    • 13
  • Mark Lathrop
    • 12
  • Florence Demenais
    • 3
    • 4
  • Marie-Hélène Dizier
    • 1
    • 2
    Email author
  1. 1.INSERM U535, Hôpital Paul BrousseVillejuif CedexFrance
  2. 2.Univ Paris-Sud, IFR69VillejuifFrance
  3. 3.INSERM, U794EvryFrance
  4. 4.Univ d’EvryEvryFrance
  5. 5.INSERM, U707ParisFrance
  6. 6.Univ Pierre et Marie Curie-Paris 6ParisFrance
  7. 7.Clinique des Maladies RespiratoiresINSERM U454, Hôpital Arnaud de VilleneuveMontpellierFrance
  8. 8.Service de Pneumologie-AllergologieHôpital NordMarseilleFrance
  9. 9.Service de PneumologieCentre Hospitalier Lyon-SudPierre BeniteFrance
  10. 10.INSERM U436ParisFrance
  11. 11.Centre de Diagnostic et Traitement de l’AsthmeHôpital TrousseauParisFrance
  12. 12.Centre National de GénotypageEvryFrance
  13. 13.INSERM, U780VillejuifFrance
  14. 14.Laboratoire d’Exploration FonctionnelleHôpital CalmetteLilleFrance
  15. 15.INSERM U408ParisFrance
  16. 16.Service de Pneumologie InfantileHôpital NeckerParisFrance
  17. 17.Département de Médecine Aigüe SpécialiséeCHU MichallonGrenobleFrance
  18. 18.Service de Pneumo-allergologieHôpital Ste MargueriteMarseilleFrance

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