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Human Genetics

, Volume 121, Issue 6, pp 737–744 | Cite as

Bivariate linkage confirms genetic contribution to fetal origins of childhood growth and cardiovascular disease risk in Hispanic children

  • Guowen Cai
  • Shelley A. Cole
  • Karin Haack
  • Nancy F. Butte
  • Anthony G. Comuzzie
Original Investigation

Abstract

Birth weight has been shown to be associated with obesity and metabolic diseases in adulthood, however, the genetic contribution is still controversial. The objective of this analysis is to explore the genetic contribution to the relationship between birth weight and later risk for obesity and metabolic diseases in Hispanic children. Subjects were 1,030 Hispanic children in the Viva La Familia Study. Phenotypes included body size, body composition, blood pressure, fasting glucose, insulin, lipids, and liver enzymes. Birth weights were obtained from Texas birth certificates. Quantitative genetic analyses were conducted using SOLAR software. Birth weight was highly heritable, as were all other phenotypes. Phenotypically, birth weight was positively correlated to childhood body size parameters. Decomposition of these phenotypic correlations into genetic and environmental components revealed significant genetic correlations, ranging from 0.30 to 0.59. Negative genetic correlations were seen between birth weight and lipids. The genome scan of birth weight mapped to a region near marker D10S537 (LOD = 2.6). The bivariate genome-wide scan of birth weight and childhood weight or total cholesterol, improved the LOD score to 3.09 and 2.85, respectively. Chromosome 10q22 harbors genes influencing both birth weight and childhood body size and cardiovascular disease risk in Hispanic children.

Keywords

Birth weight Heritability Genome wide scan Linkage analysis Obesity Childhood 

Notes

Acknowledgments

Thank the families who participated in this study, and acknowledge the contributions of Mercedes Alejandro and Marilyn Navarrete for study coordination, and Sopar Seributra for nursing and Theresa Wilson, Tina Ziba, Maurice Puyau, Firoz Vohra, Anne Adolph, Roman Shypailo, JoAnn Pratt, and Maryse Laurent for technical assistance. This work is a publication of the U.S. Department of Agriculture (USDA)/Agricultural Research Service (ARS) Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USA. This project was funded with federal funds from the NIH R01 DK59264 and from USDA/ARS under Cooperative Agreement 58-6250-51000-037.

References

  1. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC (1974) Enzymatic determination of total serum cholesterol (abstract). Clin Chem 20:470–475PubMedGoogle Scholar
  2. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62(5):1198–1211PubMedCrossRefGoogle Scholar
  3. Arends NJ, Boonstra VH, Duivenvoorden HJ, Hofman PL, Cutfield WS, Hokken-Koelega AC (2005) Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children born small for gestational age. Clin Endocrinol 62(1):44–50CrossRefGoogle Scholar
  4. Arya R, Demerath E, Jenkinson CP, Goring HH, Puppala S, Farook V, Fowler S, Schneider J, Granato R, Resendez RG, Dyer TD, Cole SA, Almasy L, Comuzzie AG, Siervogel RM, Bradshaw B, Defronzo RA, Maccluer J, Stern MP, Towne B, Blangero J, Duggirala R (2006) A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies. Hum Mol Genet 15(10):1569–1579PubMedCrossRefGoogle Scholar
  5. Barker DJP (1995) The Wellcome Foundation Lecture 1994. The fetal origins of adult disease. Proc R Soc Lond 262:37–43CrossRefGoogle Scholar
  6. Barker DJP, Winter PD, Osmond C, Margetts B, Simmonds SJ (1989) Weight in infancy and death from ischaemic heart disease. Lancet II:577–580CrossRefGoogle Scholar
  7. Butte NF, Cai G, Cole SA, Comuzzie AG (2006) Viva la Familia Study: genetic and environmental contributions to childhood obesity and its comorbidities in the Hispanic population. Am J Clin Nutr 84(3):646–654PubMedGoogle Scholar
  8. Clausson B, Lichtenstein P, Cnattingius S (2000) Genetic influence on birthweight and gestational length determined by studies in offspring of twins. BJOG 107(3):375–381PubMedCrossRefGoogle Scholar
  9. Esparza-Gordillo J, Soria, Buil A, Souto JC, L Almasy L, Blangero J, de Córdoba SR, Fontcuberta J (2004) Genetic correlation between plasma levels of C4BP isoforms containing ß chains and susceptibility to thrombosis. JMG 41:e5CrossRefGoogle Scholar
  10. Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, Beckles GL, Saaddine J, Gregg EW, Williamson DF, Narayan KM (2000) Type 2 diabetes among North American children and adolescences: an epidemiologic review and a public health perspective. J Pediatr 136:664–672PubMedCrossRefGoogle Scholar
  11. Giampietro O, Virgone E, Carneglia L, Griesi E, Calvi D, Matteucci E (2002) Anthropometric indices of school children and familiar risk factors. Prev Med 35(5):492–498PubMedCrossRefGoogle Scholar
  12. Hajek Z, Drbohlav P, Ceska R, Horinek A, Fiedler J (2000) The spectrum of lipids in the intrauterine growth retarded fetus and in the parents. Ceska Gynekol 65(3):123–127PubMedGoogle Scholar
  13. Hales CN, Barker DJP (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595–601PubMedCrossRefGoogle Scholar
  14. Hales CN, Barker DJP (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5–20PubMedCrossRefGoogle Scholar
  15. Hamvas A (2000) Disparate outcomes for very low birth weight infants: genetics, environment, or both? J Pediatr 136:427–428PubMedCrossRefGoogle Scholar
  16. Jarvelin MR (2000) Fetal and infant markers of adult heart diseases. Heart 84:219–226PubMedCrossRefGoogle Scholar
  17. Jones G, Dwyer T (2000) Birth weight, birth length, and bone density in prepubertal children: evidence for an association that may be mediated by genetic factors. Calcif Tissue Int 67(4):304–308PubMedCrossRefGoogle Scholar
  18. Lindsay RS, Kobes S, Knowler WC, Hanson RL (2002) Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of birth weight. Hum Genet 110(5):503–509PubMedCrossRefGoogle Scholar
  19. Magnus P, Gjessing HK, Skrondal A, Skjaerven R (2001) Paternal contribution to birth weight. J Epidemiol community Health 55(12):873–877PubMedCrossRefGoogle Scholar
  20. McCarthy M (1998) Weighing in on diabetes risk. Nature Genet 19:209–210PubMedCrossRefGoogle Scholar
  21. Moran A, Sinaiko AR (2000) Influence of intrauterine environment on development of insulin resistance. J Pediatr 136:567–569PubMedCrossRefGoogle Scholar
  22. Neel JV (1982) The genetics of diabetes mellitus. In: Köbberling J, Tattersall R (eds) Academic, London, pp 283–293Google Scholar
  23. Ong KKL, Phillips DI, Fall C, Poulton J, Bennett ST, Golding J, Todd JA, Dunger DB (1999) The insulin gene VNTR, type 2 diabetes and birth weight. Nat Genet 21:262–263PubMedCrossRefGoogle Scholar
  24. Parsons TJ, Power C, Logan S, Summerbell CD (1999) Childhood predictors of adult obesity: a systematic review. Int J Obes Relat Metab Disord 23(Suppl 8):S1–S107PubMedGoogle Scholar
  25. Ramadhani MK, Grobbee DE, Bots ML, Cabezas MC, Vos LE, Oren A, Uiterwaal CS (2006) Lower birth weight predicts metabolic syndrome in young adults: the atherosclerosis risk in young adults (ARYA) study. Atherosclerosis 184(1):21–27PubMedCrossRefGoogle Scholar
  26. Remacle C, Bieswal F, Reusens B (2004) Programming of obesity and cardiovascular disease. Int J Obes Relat Metab Disord 28(Suppl 3):S46–S53PubMedCrossRefGoogle Scholar
  27. Roeschlau P, Bernt E, Gruber W (1974) Enzymatic determination of total cholesterol in serum (abstract). Z Klin Chem Klin Biochem 12:226PubMedGoogle Scholar
  28. Rogers I (2003) The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life. Int J Obes Relat Metab Disord 27:755–777PubMedCrossRefGoogle Scholar
  29. Rosenbloon AL (2000) The cause of the epidemic of type 2 diabetes in children. Curr Opin Endocrinol Diabetes 7:191–196CrossRefGoogle Scholar
  30. Self SG, Liang K-Y (1987) Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 82:605–610CrossRefGoogle Scholar
  31. Sequential Oligogenic Linkage Analysis Routines (SOLAR) 2.0, Southwest Foundation for Biomedical Research, San AntonioGoogle Scholar
  32. Stern MP, Bartley M, Duggirala R, Bradshaw B (2000) Birth weight and the metabolic syndrome: thrifty phenotype or thrifty genotype? Diabetes Metab Res Rev 16:88–93PubMedCrossRefGoogle Scholar
  33. Tene CE, Espinoza-Mejia MY, Silva-Rosales NA, Giron-Carrillo JL (2003) High birth weight as a risk factor for childhood obesity. Gac Med Mex 139(1):15–20PubMedGoogle Scholar
  34. Valdez R, Athens MA, Thompson GH, Bradshaw BS, Stern MP (1994) Birth weight and adult health outcomes in a biethnic U.S. population. Diabetologia 37:624–631PubMedGoogle Scholar
  35. Vlietinck R, Derom R, Neale MC, Maes H, van Loon H, Derom C, Thiery M (1989) Genetic and environmental variation in the birth weight of twins. Behav Genet 19(1):151–161PubMedCrossRefGoogle Scholar
  36. Whitfield JB, Treloar SA, Zhu G, Martin NG (2001) Genetic and non-genetic factors affecting birth-weight and adult body mass index. Twin Res 4(5):365–370PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Guowen Cai
    • 1
  • Shelley A. Cole
    • 2
  • Karin Haack
    • 2
  • Nancy F. Butte
    • 1
  • Anthony G. Comuzzie
    • 2
  1. 1.Department of Pediatrics, USDA/ARS Children’s Nutrition Research CenterBaylor College of MedicineHoustonUSA
  2. 2.Department of GeneticsSouthwest Foundation for Biomedical ResearchSan AntonioUSA

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