Human Genetics

, Volume 121, Issue 6, pp 759–762

Extreme individual marker FST values do not imply population-specific selection in humans: the NRG1 example

  • Michelle Gardner
  • Scott Williamson
  • Ferran Casals
  • Elena Bosch
  • Arcadi Navarro
  • Francesc Calafell
  • Jaume Bertranpetit
  • David Comas
Short Report

DOI: 10.1007/s00439-007-0364-9

Cite this article as:
Gardner, M., Williamson, S., Casals, F. et al. Hum Genet (2007) 121: 759. doi:10.1007/s00439-007-0364-9

Abstract

Extreme population differentiation, as measured by the FST value, has been suggested as an indicator of recent population-specific positive selection. Elevated FST values indicating high differentiation between continental groups were previously reported on a linkage disequilibrium region in the Neuregulin 1 gene, a gene which has been associated to schizophrenia. In the present study we show evidence that high FST values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Michelle Gardner
    • 1
  • Scott Williamson
    • 2
  • Ferran Casals
    • 1
  • Elena Bosch
    • 1
  • Arcadi Navarro
    • 1
  • Francesc Calafell
    • 1
  • Jaume Bertranpetit
    • 1
  • David Comas
    • 1
  1. 1.Unitat de Biologia EvolutivaUniversitat Pompeu FabraBarcelonaSpain
  2. 2.Department of Biological Statistics and Computational BiologyCornell UniversityIthacaUSA

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