The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer
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The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.
GZ is a Scholar of the Society of University Surgeons and a recipient of a Terry Fox Foundation Research Fellowship from the National Cancer Institute of Canada. This work was supported by grants from the National Institutes of Health (to SG, R01 CA97075, as part of the PACGENE consortium), The Lustgarten Foundation for Pancreatic Cancer Research and the Ontario Cancer Research Network.