Human Genetics

, Volume 116, Issue 6, pp 525–528 | Cite as

Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study

  • Brent C. TaylorEmail author
  • Pamela J. Schreiner
  • Terence M. Doherty
  • Myriam Fornage
  • J. Jeffrey Carr
  • Steve Sidney
Short Report


A role for matrix proteins has previously been proposed in the pathogenesis of arterial calcification in the setting of atherosclerosis, and a link has been suggested between osteoporosis and arterial calcification. Our aim has been to investigate whether matrix Gla protein (MGP) T-138C, osteopontin (SPP1) T-443C, and Asp94Asp single nucleotide polymorphisms are associated with the development of arterial calcification and bone density. The individual effects of the MGP and SPP1 polymorphisms with coronary calcification are weak and not statistically significant. Bone mineral density differences at both the hip and spine do not vary statistically by genotype for any of the polymorphisms studied. Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease.


Bone Mineral Density Coronary Artery Calcification Spine Bone Mineral Density Coronary Calcification Black Female 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was partially supported by contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and N01-HC-95095 from the National Heart, Lung and Blood Institute. T.M.D. was supported by a grant from Philip Morris USA.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Brent C. Taylor
    • 1
    • 2
    Email author
  • Pamela J. Schreiner
    • 2
  • Terence M. Doherty
    • 3
  • Myriam Fornage
    • 4
  • J. Jeffrey Carr
    • 5
  • Steve Sidney
    • 6
  1. 1.Center for Chronic Disease Outcomes ResearchVA Medical Center (152/2E)MinneapolisUSA
  2. 2.Division of Epidemiology, School of Public HealthUniversity of MinnesotaMinneapolisUSA
  3. 3.Burns and Allen Research Institute, Department of Medicine, Cedars-Sinai Medical CenterDavid Geffen School of Medicine at UCLALos AngelesUSA
  4. 4.Institute of Molecular MedicineUniversity of Texas Health Science CenterHoustonUSA
  5. 5.Department of RadiologyWake Forest UniversityWinston-SalemUSA
  6. 6.Division of ResearchKaiser Permanente Medical Care ProgramOaklandUSA

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