Human Genetics

, Volume 118, Issue 2, pp 179–184 | Cite as

Familial aggregation in lone atrial fibrillation

  • Patrick T. Ellinor
  • Danita M. Yoerger
  • Jeremy N. Ruskin
  • Calum A. MacRae
Original Investigation


Atrial fibrillation (AF) is the most common clinical arrhythmia and a major risk factor for stroke. To investigate the role of genetic factors in a typical clinical population, we determined the extent of familial aggregation in patients with lone AF. To estimate the relative risk to family members, the prevalence of AF for each class of relative was compared to the prevalence in the comparable age and sex group from the general population. Family members had an increased relative risk of AF compared to the general population (risk ratio; 95% confidence intervals): sons (8.1; 2.0–32), daughters (9.5; 1.3–67), brothers (70; 47–102), sisters (34; 14–80), mothers (4.0; 2.5–6.5) and fathers (2.0; 1.2–3.6). Relatives of probands with lone AF are at a substantially increased risk of developing this arrhythmia suggesting a Mendelian genetic contribution to the etiology of this common trait.


Heart Genetics Arrhythmia 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Patrick T. Ellinor
    • 1
  • Danita M. Yoerger
    • 1
  • Jeremy N. Ruskin
    • 1
  • Calum A. MacRae
    • 1
  1. 1.Cardiac Arrhythmia Service and Cardiovascular Research CenterMassachusetts General HospitalBostonUSA

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