Human Genetics

, Volume 116, Issue 3, pp 192–199 | Cite as

Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis

  • Fotini K. Kavvoura
  • John P. A. Ioannidis
Original Investigation


A meta-analysis assessed whether the Ala45Thr polymorphism of the neurogenic differentiation 1 (NEUROD1) gene is associated with increased risk of diabetes mellitus type 1 (T1D) or type 2 (T2D). Fourteen case-control studies were analyzed, including genotype data on 3,057 patients with diabetes (T1D n=1,213, T2D n=1,844) and 2,446 controls. Overall and race-specific summary odds ratios (ORs) were obtained with fixed and random effects models. The Thr allele did not significantly increase the overall risk for T1D (OR 1.27 [0.94–1.71], P=0.12) or T2D (OR 1.07 [0.90–1.28], P=0.46). The Thr allele conferred increased susceptibility in subjects of Asian racial descent to T1D (OR 1.88 [1.10–3.21], P=0.020), but not to T2D (OR 1.08 [0.74–1.56], P=0.70). There was no association in subjects of European descent (OR 0.97 [0.76–1.23], P=0.80 for T1D; OR 1.03 [0.88–1.21], P=0.68 for T2D). Larger studies seemed to show more conservative estimates for the association with T1D (P=0.083). The Ala45Thr polymorphism of the NEUROD1 gene has no effect on susceptibility to T2D. It may however be a risk factor for susceptibility to T1D, in particular for subjects of Asian descent, although bias cannot be totally excluded.


Beta Cell European Descent Insulin Gene Asian Descent Neurogenic Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We are thankful to Dr. David Owerbach and Dr. Lars Hansen for providing us with additional data from their studies.


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Clinical and Molecular Epidemiology Unit, Department of Hygiene and EpidemiologyUniversity of Ioannina School of MedicineIoanninaGreece
  2. 2.Biomedical Research InstituteFoundation for Research and Technology-HellasIoanninaGreece
  3. 3.Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts-New England Medical CenterTufts University School of MedicineBostonUSA

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