Human Genetics

, Volume 114, Issue 4, pp 396–396

The assertion that a G21V mutation in AGTR2 causes mental retardation is not supported by other studies

  • Jeanette Erdmann
  • Steffen Dähmlow
  • Marco Guse
  • Roland Hetzer
  • Vera Regitz-Zagrosek
Letter to the Editors
  • 104 Downloads

References

  1. Erdmann J, Guse M, Kallisch H, Fleck E, Regitz-Zagrosek V (2000) Novel intronic polymorphism (+1675G/A) in the human angiotensin II subtype 2 receptor gene. Hum Mutat 15:487CrossRefGoogle Scholar
  2. Regitz-Zagrosek V, Friedel N, Heymann A, Bauer P, Neuss M, Rolfs A, Steffen C, Hildebrandt A, Hetzer R, Fleck E (1995) Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation 91:1461–1471PubMedGoogle Scholar
  3. Schmieder RE, Erdmann J, Delles C, Jacobi J, Fleck E, Hilgers K, Regitz-Zagrosek V (2001) Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. J Am Coll Cardiol 37:175–182CrossRefPubMedGoogle Scholar
  4. Vervoort VS, Beachem MA, Edwards PS, Ladd S, Miller KE, de Mollerat X, Clarkson K, DuPont B, Schwartz CE, Stevenson RE, Boyd E, Srivastava AK (2002) AGTR2 mutations in X-linked mental retardation. Science 296:2401–2403PubMedGoogle Scholar
  5. Warnecke C, Willich T, Holzmeister J, Bottari SP, Fleck E, Regitz-Zagrosek V (1999) Efficient transcription of the human angiotensin II type 2 receptor gene requires intronic sequence elements. Biochem J 340:17–24CrossRefPubMedGoogle Scholar
  6. Ylisaukko-oja T, Rehnstrom K, Vanhala R, Tengstrom C, Lahdetie J, Jarvela II (2004) Identification of two AGTR2 mutations in male patients with non-syndromic mental retardation. Hum Genet 114:211-213PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Jeanette Erdmann
    • 1
  • Steffen Dähmlow
    • 2
  • Marco Guse
    • 2
  • Roland Hetzer
    • 2
  • Vera Regitz-Zagrosek
    • 2
  1. 1.Universitätsklinikum Schleswig-Holstein Campus Lübeck Medizinische Klinik IILübeckGermany
  2. 2.DHZBBerlinGermany

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