Human Genetics

, Volume 114, Issue 3, pp 272–279 | Cite as

Haplotype mapping of the bronchiolitis susceptibility locus near IL8

  • Jeremy Hull
  • Kate Rowlands
  • Elizabeth Lockhart
  • Mike Sharland
  • Catrin Moore
  • Neil Hanchard
  • Dominic P. Kwiatkowski
Original Investigation
First Online:
Received:
Accepted:

Abstract

Susceptibility to viral bronchiolitis, the commonest cause of infant admissions to hospital in the industrialised world, is associated with polymorphism at the IL8 locus. Here we map the genomic boundaries of the disease association by case-control analysis and TDT in 580 affected UK infants. Markers for association mapping were chosen after determining patterns of linkage disequilibium across the surrounding region of chromosome 4q, a 550-kb segment containing nine genes, extending from AFP to PPBP. The region has three major clusters of high linkage disequilibrium and is notable for its low haplotypic diversity. We exclude adjacent chemokine genes as the cause of the association, and identify a disease-associated haplotype that spans a 250-kb region from AFM to IL8. In between these two genes there is only one structural feature of interest, a novel gene RASSF6, which is predicted to encode a Ras effector protein.

Keywords

Respiratory Syncytial Virus Bronchiolitis Haplotype Block Disease Association Respiratory Syncytial Virus Bronchiolitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgements

The authors are very grateful to the lead paediatricians and their teams at the participating hospitals for coordinating sample collection. The study was funded by the Medical Research Council, UK.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Jeremy Hull
    • 1
  • Kate Rowlands
    • 1
  • Elizabeth Lockhart
    • 2
  • Mike Sharland
    • 2
  • Catrin Moore
    • 3
  • Neil Hanchard
    • 1
    • 4
  • Dominic P. Kwiatkowski
    • 1
    • 4
  1. 1.University Department of Paediatrics, Level 4John Radcliffe HospitalOxfordUK
  2. 2.Paediatric Infectious Diseases UnitSt Georges HospitalLondonUK
  3. 3.Nuffield Department of Clinical MedicineUniversity of OxfordOxfordUK
  4. 4.Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK

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