Human Genetics

, Volume 113, Issue 4, pp 311–315 | Cite as

Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children

  • Kimiko Yamakawa-Kobayashi
  • Hisako Yanagi
  • Kazue Endo
  • Tadao Arinami
  • Hideo Hamaguchi
Original Investigation


Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism. One physiologic role of EL is thought to be hydrolysis of high-density lipoprotein (HDL) phospholipid, although the precise function of endothelial lipase has yet to be fully clarified. Furthermore, genetic variation in EL has been suggested to influence serum HDL-C levels. In the present study, we detected two common single nucleotide polymorphisms in the EL gene associated with serum HDL cholesterol levels in healthy school-aged children. Our data support the hypothesis that variations in the EL gene are one of the genetic determinants of serum HDL-C levels.


Serum Lipid Level Hepatic Lipase Endothelial Lipase Tight Linkage Disequilibrium Plasma Lipoprotein Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We are grateful to the subjects for their participation in our study. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Kimiko Yamakawa-Kobayashi
    • 1
    • 3
  • Hisako Yanagi
    • 2
  • Kazue Endo
    • 2
  • Tadao Arinami
    • 1
  • Hideo Hamaguchi
    • 1
  1. 1.Department of Medical Genetics, Institute of Basic Medical SciencesUniversity of TsukubaTsukuba Japan
  2. 2.Institute of Community MedicineUniversity of TsukubaTsukuba Japan
  3. 3.School of Food and Nutritional SciencesUniversity of ShizuokaShizuoka Japan

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