Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
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Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism. One physiologic role of EL is thought to be hydrolysis of high-density lipoprotein (HDL) phospholipid, although the precise function of endothelial lipase has yet to be fully clarified. Furthermore, genetic variation in EL has been suggested to influence serum HDL-C levels. In the present study, we detected two common single nucleotide polymorphisms in the EL gene associated with serum HDL cholesterol levels in healthy school-aged children. Our data support the hypothesis that variations in the EL gene are one of the genetic determinants of serum HDL-C levels.
KeywordsSerum Lipid Level Hepatic Lipase Endothelial Lipase Tight Linkage Disequilibrium Plasma Lipoprotein Metabolism
We are grateful to the subjects for their participation in our study. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
- Glomset JA, Norum KR (1973) The metabolic role of lecithin: cholesterol acyltransferase: perspectives form pathology. Adv Lipid Res 11:1-65Google Scholar
- Gordon DJ, Rifkind BM (1989) High-density lipoprotein—the clinical implications of recent studies. N Engl J Med 321:1311–1316Google Scholar
- Tall AR, Breslow JL, Rubin EM (2002) Genetic disorders affecting plasma high-density lipoproteins. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular basis of inherited disease, 8th edn, vol 2. McGraw Hill, New York, pp 2915–2936Google Scholar