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Human Genetics

, Volume 111, Issue 3, pp 270–277 | Cite as

A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers

  • Rene Goedde
  • Stephen Sawcer
  • Stefan Boehringer
  • Bianca Miterski
  • Eckhart Sindern
  • Michael Haupts
  • Sebastian Schimrigk
  • Alastair Compston
  • Joerg T. Epplen
Original Investigation

Abstract.

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Genome Screen Multiple Sclerosis Case International Human Genome Sequencing Consortium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Rene Goedde
    • 1
  • Stephen Sawcer
    • 5
  • Stefan Boehringer
    • 1
  • Bianca Miterski
    • 1
  • Eckhart Sindern
    • 2
  • Michael Haupts
    • 3
  • Sebastian Schimrigk
    • 4
  • Alastair Compston
    • 5
  • Joerg T. Epplen
    • 1
  1. 1.Department of Molecular Human Genetics, Ruhr-University, Universitätsstrasse 150, 44780 Bochum, GermanyGermany
  2. 2.Department of Neurology, Kliniken Bergmannsheil, Ruhr-University, BochumGermany
  3. 3.Department of Neurology, Knappschaftskrankenhaus, Ruhr-University, BochumGermany
  4. 4.Department of Neurology, St. Josef-Hospital, Ruhr-University, BochumGermany
  5. 5.University of Cambridge, Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQUK

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