Human Genetics

, Volume 110, Issue 4, pp 348–350

A novel locus for Usher syndrome type I, USH1G, maps to chromosome 17q24–25

  • Mirna Mustapha
  • Éliane Chouery
  • Delphine Torchard-Pagnez
  • Sylvie Nouaille
  • Awni Khrais
  • Fouad N. Sayegh
  • André Mégarbané
  • Jacques Loiselet
  • Mark Lathrop
  • Christine Petit
  • Dominique Weil
Original Investigation

DOI: 10.1007/s00439-002-0690-x

Cite this article as:
Mustapha, M., Chouery, É., Torchard-Pagnez, D. et al. Hum Genet (2002) 110: 348. doi:10.1007/s00439-002-0690-x

Abstract.

Usher syndrome (USH) is an autosomal recessive disorder associated with sensorineural hearing impairment and progressive visual loss attributable to retinitis pigmentosa. This syndrome is both clinically and genetically heterogeneous. Three clinical types have been described of which type I (USH1) is the most severe. Six USH1 loci have been identified. We report a Palestinian consanguineous family from Jordan with three affected children. In view of the combination of profound hearing loss, vestibular dysfunction, and retinitis pigmentosa in the patients, we classified the disease as USH1. Linkage analysis excluded the involvement of any of the known USH1 loci. A genome-wide screening allowed us to map this novel locus, USH1G, in a 23-cM interval on chromosome 17q24–25. The USH1G interval overlaps the intervals for two dominant forms of isolated hearing loss, namely DFNA20 and DFNA26. Since several examples have been reported of syndromic and isolated forms of deafness being allelic, USH1G, DFNA20, and DFNA26 might result from alterations of the same gene. Finally, a mouse mutant, jackson shaker (js), with deafness and circling behavior has been mapped to the murine homologous region on chromosome 11.

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Mirna Mustapha
    • 1
  • Éliane Chouery
    • 2
  • Delphine Torchard-Pagnez
    • 5
  • Sylvie Nouaille
    • 1
  • Awni Khrais
    • 3
  • Fouad N. Sayegh
    • 4
  • André Mégarbané
    • 2
  • Jacques Loiselet
    • 2
  • Mark Lathrop
    • 5
  • Christine Petit
    • 1
  • Dominique Weil
    • 1
  1. 1.Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris cedex 15France
  2. 2.Laboratoire de Biologie Moléculaire, Faculté de Médecine, Université Saint–Joseph, BeyrouthLebanon
  3. 3.Ophthalmology Department, Ibn Al Haytham Hospital, PO 940614, AmmanJordan
  4. 4.Jabal Amman, 3rd Circle, PO 815447, Amman 11180Jordan
  5. 5.Centre National de Génotypage, 2 Rue Gaston Crémieux, 91057 Évry cedexFrance

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