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Molecular and General Genetics MGG

, Volume 254, Issue 1, pp 93–97 | Cite as

The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase δ

  • Yuichi Iino
  • Masayuki Yamamoto
SHORT COMMUNICATION

Abstract

The cdc6 mutants of Schizosaccharomyces pombe have been classified as being defective in progression through the G2 phase of the cell cycle. We cloned an S. pombe gene that could complement the temperature-sensitive growth of the cdc6-23 mutant. Unexpectedly, the cloned gene was allelic to pol3, which encodes the catalytic subunit of DNA polymerase δ. Integration mapping confirmed that cdc6 and pol3 are identical. The cdc6-23 mutant carries one amino acid substitution in the conserved N3 region of Pol3.

Key wordsSchizosaccharomyces pombe   Cell cycle cdc6   pol3   DNA polymerase δ 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Yuichi Iino
    • 1
  • Masayuki Yamamoto
    • 1
  1. 1.Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, P.O. Hongo, Tokyo 113, JapanJP

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