Molecular Genetics and Genomics

, Volume 294, Issue 4, pp 931–940 | Cite as

Disease association of human tumor suppressor genes

  • Asim Bikas DasEmail author
Original Article


The multifactorial disease, cancer, frequently emerges due to perturbations in tumor suppressor genes (TSGs). However, a growing number of noncanonical target genes of TSGs and the highly interconnected nature of the human interactome reveal that the functions of TSGs are not limited to cancer-specific events. The various functions of TSGs lead to the assumption that cancer is linked with other human disorders. Therefore, a disease–gene association network of TSGs (TSDN) was constructed by integrating protein–protein interaction networks of TSGs (TSN) with Morbid Map in Online Mendelian Inheritance in Man. The TSDN revealed links between TSGs and 22 different human disorders including cancer and indicated disease–disease associations. In addition, high-density functional protein clusters in the TSN showed cohesive and overlapping disease–TSG associations, which proved the prevalent role of TSGs in various human diseases beyond cancer. The presence of overlapping disease–gene modules and disease–disease associations via the TSN demonstrated that other diseases can serve as possible roots of the life-threatening disease cancer. Therefore, a disease association map of TSGs could be a promising tool for exploring intricate relationships between cancer and other diseases for the early prediction of cancer and the understanding of disease etiology.


Tumor suppressor gene Cancer Protein–protein interaction network Disease–gene association 



I thank Mr.Kuntal Bhusan (Bio-Sciences R&D Division, TCS, Pune, India) for discussion regarding the statistical analysis of networks, Shiv Prasad (Software developer,, Hyderabad, India) for assistance in writing the code in R, and Dr Urmila Saxena (NIT Warangal) for the critically reading of the manuscript and her constructive suggestion. I also thank the National Institute of Technology, Warangal for providing computational facilities.

Compliance with ethical standards

Conflict of interest

The author declares he has no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed by the author.

Supplementary material

438_2019_1557_MOESM1_ESM.pdf (85.7 mb)
Supplementary material 1 (PDF 87757 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of BiotechnologyNational Institute of Technology WarangalWarangalIndia

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