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Molecular Genetics and Genomics

, Volume 291, Issue 1, pp 121–128 | Cite as

ADAMTS7 locus confers high cross-race risk for development of coronary atheromatous plaque

  • Ling You
  • Lun Tan
  • Lei Liu
  • Rufei Shen
  • Sandip Chaugai
  • Dao Wen Wang
  • Wei Cui
Original Article

Abstract

Genome-wide association studies of coronary artery disease (CAD) have recently identified a new susceptibility locus, ADAMTS7, in subjects of European ancestry. However, the significance of this locus in Chinese populations has not been identified. Therefore, this study was designed to evaluate the effect of rs3825807, a non-synonymous variant in the prodomain of the ADAMTS7 protease, on CAD risk and atherosclerosis severity in a Chinese population. We performed genetic association analyses in two independent case–control cohorts, which included a total of 8154 participants. Additionally, the association between the ADAMTS7 rs3825807 genotype and the proportion of CAD patients with 3- and 1-vessel disease was tested. We found that ADAMTS7 rs3825807 was associated with susceptibility to CAD in a Chinese population [odds ratio (OR) = 1.15, 95 % confidence interval (CI) = 1.05–1.26, P = 0.002]. The association remained significant after adjusting for clinical covariates (adjusted OR = 1.12, 95 % CI = 1.02–1.24, P = 0.02). Among 3741 angiographically documented CAD patients, the rs3825807 risk allele showed a significant association with disease severity (P = 0.04, trend P = 0.02). Additionally, 3-vessel disease demonstrated a strong and direct association with ADAMTS7 rs3825807 gene dosage (P = 0.02). Overall, our findings indicate that the significant associations observed between this coding variant in ADAMTS7 and the risk of CAD development are cross-ethnic, and the gene dosage is consistent with the degree of coronary atheromatous burden.

Keywords

ADAMTS7 Atherosclerosis severity Coronary artery disease 

Notes

Acknowledgments

We are particularly grateful to all volunteers for participating in the present study and to the medical personnel of Tongji Hospital and The Second Hospital of Hebei Medical University for their kind assistance in collecting the data and samples.

Compliance with ethical standards

Funding

This study was funded by the research grants from National ‘973’ Project (2012CB518004), and National Nature Science Foundation of China (30930039, 81100066).

Conflict of interest

Ling You, Lun Tan, Lei Liu, Rufei Shen, Sandip Chaugai, Dao Wen Wang, Wei Cui declares that he/she has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

438_2015_1092_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 13 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Division of CardiologyThe Second Hospital of Hebei Medical UniversityShijiazhuangPeople’s Republic of China
  2. 2.Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China

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