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Molecular Genetics and Genomics

, Volume 290, Issue 4, pp 1485–1491 | Cite as

Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes

  • Mathias Rask-AndersenEmail author
  • Markus Sällman Almén
  • Lars Lind
  • Helgi B. Schiöth
Original Paper

Abstract

Genome-wide association studies (GWAS) have identified common genetic factors influencing body mass as well as body adiposity. The functional implications of these loci are currently under investigation. Intense scrutiny of the body mass-associated FTO locus revealed age-specific effects, or a weakened effect in elderly populations. In this study, we aimed to determine the effects of single nucleotide polymorphisms (SNPs) representing 35 GWAS-identified body mass- and adiposity-associated genetic loci. In our analysis, 949 participants of the Prospective Investigation of the Vasculature in Uppsala Seniors cohort were included. All participants were born between 1920 and 1924. Data were available for 474 male and 475 female participants at age 70 and 380 male and 390 female participants at age 75. Genetic associations with BMI and change in BMI from age 70 to 75 were analyzed. In our analysis, rs10968576, an intronic SNP within the LINGO2 (LERN3, LRRN6C) gene, was associated with body mass in a cross section of elderly Swedes at age 70. This is the first study to replicate the association of a LINGO2-related genetic variant with body mass in an independent cohort of elderly citizens.

Keywords

Body mass Obesity LINGO2 rs10968576 

Notes

Acknowledgments

The studies were supported by the Swedish Research Council and the Swedish Heart and Lung Foundation. MRA was supported by a grant from The Swedish Brain Foundation (Hjärnfonden). Genotyping was performed by the SNP&SEQ Technology Platform in Uppsala, which is supported by Uppsala University, Uppsala University Hospital, Science for Life Laboratory—Uppsala, and the Swedish Research Council (Contracts 80576801 and 70374401).

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Mathias Rask-Andersen
    • 1
    Email author
  • Markus Sällman Almén
    • 1
    • 2
  • Lars Lind
    • 3
  • Helgi B. Schiöth
    • 1
  1. 1.Department of Neuroscience, Unit of Functional PharmacologyUppsala University, BMCUppsalaSweden
  2. 2.Department of Medical Biochemistry and MicrobiologyUppsala University, BMCUppsalaSweden
  3. 3.Department of Medical Sciences, Cardiovascular EpidemiologyUppsala UniversityUppsalaSweden

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