Association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility: a meta-analysis
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To date, epidemiological studies have assessed the association between CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility. However, the results of these studies remained controversial. We aimed to examine the associations by conducting a meta-analysis of case–control studies. A total of 11 studies including 5,093 cases and 5,941 controls evaluated the association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility. No significantly associations were found in all genetic models (CC vs. AA: OR = 1.14, 95 % CI = 0.93–1.40; AC vs. AA: OR = 1.05, 95 % CI = 0.91–1.20; dominant model: OR = 1.08, 95 % CI = 0.95–1.24; recessive model: OR = 1.10, 95 % CI = 0.95–1.28). In the subgroup analysis by ethnicity or source of controls, there were still no significant associations detected in all genetic models. This meta-analysis suggested the CYP1A2-164 A/C polymorphism was not a risk factor for increasing colorectal cancer, further large and well-designed studies are needed to confirm these conclusions.
KeywordsMeta-analysis CYP1A2 Polymorphism Colorectal cancer
This study was supported by Natural Science Foundation of The People’s Republic of China (No.81072175, 81102010, 81202096, 81372854), Shanghai Science and Technology Committee (No.114119a7500, No.06DZ19505 and No.13NM141504) and Chanhai Hospital 1255 discipline construction projects (No.CH125530400). The funders had no roles in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.
Conflict of interest
The authors declare that they have no conflict of interest.
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