Parasitology Research

, Volume 85, Issue 12, pp 1025–1031 | Cite as

Taenia crassiceps cysticercosis: A role for prostaglandin E2 in susceptibility

  • Luis I. Terrazas
  • Rafael Bojalil
  • Miriam Rodriguez-Sosa
  • Tzipe Govezensky
  • Carlos Larralde
ORIGINAL PAPER

Abstract

Several biological factors are involved in susceptibility and resistance to murine cysticercosis. A substantial body of evidence implies prostaglandins as potent regulators of immune responses during parasitic diseases. Here we evaluated the role played by prostaglandin E2 in cysticercosis. Mice were treated in vivo with prostaglandin E2 or with indomethacin (a prostaglandin E2 synthesis inhibitor) before infection. Parasite growth was enhanced by prostaglandin treatment, which provoked poor Con-A responses, low Th1-type cytokines secretion, and high levels of IL-6 and IL-10. In contrast, mice receiving indomethacin showed a reduction in parasite load parallel to a strong Con-A response and high levels of IL-2 and IFN-γ, concomitantly with a decrease in IL-4, IL-6 and IL-10 production. Indirect in vitro studies suggest that an important source of prostaglandin E2 production could be related to host's adherent cells. However, prostaglandin E2 from parasite origin cannot be discarded.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Luis I. Terrazas
    • 1
  • Rafael Bojalil
    • 1
  • Miriam Rodriguez-Sosa
  • Tzipe Govezensky
    • 2
  • Carlos Larralde
    • 2
  1. 1.Department of Immunology, Instituto Nacional de Cardiología “Ignacio Chávez”. Juan Badiano No. 1, Col. Sección XVI, Tlalpan, México, D.F. 14080 Tel.: (525) 573-29-11; Fax: (525) 573-09-94MX
  2. 2.Department of Immunology, Instituto de Investigaciones Biomédicas, UNAM. Ciudad Universitaria, México D.F. 04510MX

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