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Parasitology Research

, Volume 83, Issue 5, pp 489–491 | Cite as

Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro

  • Anthony E. T. Yeo
  • Michael D. Edstein
  • G. Dennis Shanks
  • Karl H. Rieckmann
ORIGINAL PAPER

Abstract

The effect of doxycycline, obtained from human volunteers administered doxycycline, on the minimum inhibitory concentration (MIC) of atovaquone was determined against the K1 and FC27 isolates of Plasmodium falciparum in vitro. Doxycycline concentrations ranging from 0.10-1.18 μg/ml added to atovaquone produced MIC ratios [atovaquone + doxycycline/atovaquone alone] ranging from 0.38 to 0.70. These results suggest that the antimalarial activity of atovaquone is potentiated by doxycycline. Additionally, these drugs may be rational partners for the treatment and prophylaxis of falciparum malaria.

Keywords

Malaria Minimum Inhibitory Concentration Inhibitory Concentration Plasmodium Doxycycline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Anthony E. T. Yeo
    • 1
  • Michael D. Edstein
    • 1
  • G. Dennis Shanks
    • 2
  • Karl H. Rieckmann
    • 1
  1. 1.Army Malaria Research Unit, Liverpool Military Area, NSW 2174, AustraliaAU
  2. 2.US Army Medical Research Unit Kenya, Unit 64109, Box 401, APO AE 09831-4109, USAKE

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