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Parasitology Research

, Volume 83, Issue 4, pp 319–325 | Cite as

Experimental Blastocystis hominis infection in laboratory mice

  • K. T. Moe
  • M. Singh
  • J. Howe
  • L. C. Ho
  • S. W. Tan
  • X. Q. Chen
  • G. C. Ng
  • E. H. Yap
REVIEW ARTICLE

Abstract

Young (less than 8 weeks old) immunocompetent BALB/c mice became infected with Blastocystis hominis after inoculation of fecal cysts orally and of in vitro axenic-culture forms intracecally. This study confirmed that the fecal cyst was the form responsible for external transmission and that the mode of transmission was by the fecal-oral route. The infection was self-limiting and the infected BALB/c mice appeared normal except that some of them showed weight loss and lethargy. Both vacuolar and granular forms were found in the cecum, but only cyst forms were observed in the colon. Histological examination of the cecum and colon showed intense inflammatory-cell infiltration, edematous lamina propria, and mucosal sloughing. It is apparent that although B. hominis is not invasive, it is capable of causing pathogenesis in BALB/c mice.

Keywords

Histological Examination Lamina Propria Cyst Form Laboratory Mouse Granular Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. T. Moe
    • 1
  • M. Singh
    • 1
  • J. Howe
    • 1
  • L. C. Ho
    • 1
  • S. W. Tan
    • 1
  • X. Q. Chen
    • 1
  • G. C. Ng
    • 1
  • E. H. Yap
    • 1
  1. 1.Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge Crescent, Singapore 119260, Republic of Singapore Fax: (65) 77 66 872; e-mail: micmulki @ nus.sgSG

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